Pharmaco-metabolomics and metabolomics: A new tool in precision medicine? - 21/02/26

Doi : 10.1016/j.therap.2025.11.012

Antonin Lamazière ^a,^{^{1
These authors contributed equally to this work.},}^⁎ , Erwan Werner ^b, Caroline Barau ^c,^{^{2
Participants in the “Pharmacology and translational research” round table of the Giens 2025 Workshops.}}, Jean-François Benoist ^d,^{^{2
Participants in the “Pharmacology and translational research” round table of the Giens 2025 Workshops.}}, Hélène Blasco ^e,^{^{2
Participants in the “Pharmacology and translational research” round table of the Giens 2025 Workshops.}}, David Bonnel ^f,^{^{2
Participants in the “Pharmacology and translational research” round table of the Giens 2025 Workshops.}}, Abd El Kader Ait Tayeb ^g,^{^{2
Participants in the “Pharmacology and translational research” round table of the Giens 2025 Workshops.}}, Florence Castelli ^h,^{^{2
Participants in the “Pharmacology and translational research” round table of the Giens 2025 Workshops.}}, Benjamin Guiot ^i,^{^{2
Participants in the “Pharmacology and translational research” round table of the Giens 2025 Workshops.}}, Najiba Lahlou ^j,^{^{2
Participants in the “Pharmacology and translational research” round table of the Giens 2025 Workshops.}}, Magali Sarafian ^k,^{^{2
Participants in the “Pharmacology and translational research” round table of the Giens 2025 Workshops.}}, Olivier Blin ^l,^{^{2
Participants in the “Pharmacology and translational research” round table of the Giens 2025 Workshops.}}, Céline Verstuyft ^m,^{^{1
These authors contributed equally to this work.}}

^a Département de métabolomique clinique, centre de recherche Saint-Antoine, hôpital Saint-Antoine, AP–HP, Sorbonne université, 75000 Paris, France

^b Institut Servier de médecine translationnelle, institut Servier de recherche et développement Paris-Saclay, 91190 Gif-sur-Yvette, France

^c Plateforme de ressources biologiques, hôpitaux universitaires Henri-Mondor AP–HP, 94000 Créteil, France

^d Service de biochimie, CHU Necker enfants malades, université Paris-Saclay, 75000 Paris, France

^e Service de biochimie et biologie moléculaire, Inserm, Imaging Brain & Neuropsychiatry iBraiN U1253, CHU de Tours, université de Tours, 37000 Tours, France

^f Aliri, Parc Eurasanté, 59120 Loos, France

^g Inserm, physiologie et physiopathologie endocriniennes, université Paris-Saclay, centre de recherche clinique Paris-Saclay, hôpital Bicêtre, AP–HP, 94276 Le Kremlin-Bicêtre, France

^h Département médicaments et technologies pour la santé (DMTS), CEA, INRAE, MetaboHUB-IDF, université Paris-Saclay, 91191 Gif-sur-Yvette, France

ⁱ Institution publique de santé, Fr Bio Net, CNCR, 75014 Paris, France

^j Hormone Department, BPR-AS, 45700 Pannes, France

^k Bioaster institut de microbiologie, 69000 Lyon, France

^l Service de pharmacologie clinique et pharmacosurveillance, Inserm UMR 1106, AP–HM, Aix-Marseille université, 13000 Marseille, France

^m Service de génétique moléculaire, pharmacogénétique et hormonologie de Bicêtre, faculté de médecine, hôpital de Bicêtre, Inserm UMR 1018, CESP, MOODS Team, AP–HP, université Paris-Saclay, 94276 Le Kremlin-Bicêtre, France

^⁎ Corresponding author. Département de métabolomique clinique, centre de recherche Saint-Antoine, hôpital Saint-Antoine, Sorbonne université, AP–HP, 75000 Paris, France. Département de métabolomique clinique, centre de recherche Saint-Antoine, hôpital Saint-Antoine, Sorbonne université, AP–HP Paris 75000 France

Summary

Precision medicine aims to integrate individual patient characteristics into therapeutic decisions. Metabolomics and pharmaco-metabolomics enable direct exploration of the biological phenotype through comprehensive analysis of the metabolites present in an organism. These approaches provide an integrative perspective that considers the interactions among the genome, environment, microbiota, and lifestyle, paving the way for better prediction of treatment efficacy and the prevention of adverse events. However, their implementation faces technical, analytical, organizational, and regulatory hurdles. The Giens 2025 Workshops brought together academic, institutional, and industrial experts to identify the ambitions of pharmaco-metabolomics and the obstacles to its development, ultimately proposing key recommendations. These recommendations focus on standardizing practices, enhancing professional training, improving data interoperability, and increasing the accessibility of analytical tools. Thus, pharmaco-metabolomics is positioned as a significant lever for integrating the biological phenotype into personalized medicine by 2030.

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Keywords : Metabolomics, Pharmaco-metabolomics, Personalized medicine, Biomarkers, Standardization

Plan

Abbreviations

Introduction

Methodology

Definitions and concepts

Use cases

Clinical exploration of pathophysiological situations

Pharmacology and therapeutics

Constraints and challenges

Recommendations

Recommendation 1 – Methodology

Recommendation 2 – Pre-analytics

Recommendation 3 – Analytical

Recommendation 4 – Standardization and annotation

Recommendation 5 – Clinical interpretation and multidisciplinarity

Organization and valorization

Conclusion and perspectives

☆	The opinions, and proposals from the Giens Workshops presented in this article reflect the views of the authors and do not necessarily represent those of their organizations.

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Vol 81 - N° 1

P. 10-18 - janvier 2026 Retour au numéro

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Pharmaco-métabolomique et métabolomique : un nouvel outil en médecine de précision ?
Antonin Lamazière, Erwan Werner, Caroline Barau, Jean-François Benoist, Hélène Blasco, David Bonnel, Abd El Kader Ait-Tayeb, Florence Castelli, Benjamin Guiot, Najiba Lahlou, Magali Sarafian, Olivier Blin, Céline Verstuyft

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Pharmaco-metabolomics and metabolomics: A new tool in precision medicine? - 21/02/26

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