Subcutaneous antibiotic therapy: effectiveness and safety in a real-world cohort of 136 patients - 22/07/26
Abstract |
Background |
Subcutaneous antibiotic administration is increasingly considered an alternative to intravenous therapy in selected patients. It can facilitate early discharge and outpatient management when oral treatment is not possible.
Methods |
We retrospectively evaluated the effectiveness and tolerability of subcutaneous ceftriaxone, teicoplanin, and ertapenem in adults treated in a university infectious diseases center between January 2017 and February 2023.
Results |
A total of 136 patients were included. The median age was 64 years (interquartile range 53–78), and 38% were older than 75 years. Bone and joint infections (45.6%), urinary tract infections (25.7%), and pulmonary infections (22.1%) were the most frequent indications. Overall clinical cure was achieved in 126/136 patients (92.6%). Cure rates reached 100% for urinary tract and cardiovascular infections and 96.7% for pulmonary infections. Twenty-one adverse events were reported, including injection site pain in 11 patients (8.1%). No severe local complication occurred. Teicoplanin trough concentrations, available in three patients with adverse events, remained within the therapeutic range.
Conclusion |
These findings support subcutaneous ceftriaxone, teicoplanin, and ertapenem administration as a safe and effective alternative when oral or intravenous therapy is not feasible.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Subcutaneous antibiotics were associated with a 92.6% overall clinical cure rate. |
• | Injection-site pain occurred in 8.1% of patients. |
• | No severe local adverse event was observed. |
• | Subcutaneous therapy may be an alternative when intravenous access is problematic. |
Keywords : Subcutaneous antibiotics, Ceftriaxone, Ertapenem, Teicoplanin, Urinary tract infection
Plan
Vol 56 - N° 5
Article 105314- juillet 2026 Retour au numéro
Article précédent
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