The process of flash sterilization has evolved since its inception. The process of flash sterilization continues to evolve focusing on what is needed to guarantee that flash sterilization is safe, effective and will ultimately ensure patient safety and reduce surgical site infections. Today’s practice is more complex with the necessity for increased knowledge and staff competencies of the entire sterilization process. The way that regulatory agencies review or assess a facility’s process for flash sterilization is also changing. The sterilization processes are assessed to ensure that they deliver safe products for patients. Because of the increased incidences of surgical site infections and health care–associated infections, it is imperative that all steps of the sterilization process be followed consistently and conscientiously. Flash sterilization can be a safe and effective process for the sterilization of instruments intended for immediate use during operative/invasive procedures. Perioperative managers should review and audit current practices and implement a workable, continuous, quality-improvement program.