Increased Intrasubject Variability in Response Time in Youths With Bipolar Disorder and At-Risk Family Members - 07/08/11
, Melissa H. Rooney, B.A., Martha Skup, B.S., Daniel S. Pine, M.D., Ellen Leibenluft, M.D.Disclosure: The authors report no conflicts of interest.
Abstract |
Objective |
Deficits in sustained attention may represent an endophenotype for bipolar disorder (BD). One heritable measure of sustained attention is intrasubject variability in response time (ISV-RT). We tested the hypothesis that, compared with controls, both youths with BD and those at familial risk for the disorder would have increased ISV-RT.
Method |
Subjects were 28 patients with BD, 26 unaffected youths with a first-degree relative with BD, and 24 control youths without an affected relative, all aged 7 to 17 years. Subjects completed the Flanker Continuous Performance Test.
Results |
Bipolar disorder and at-risk youths had increased ISV-RT, compared with the controls. Differences were independent of comorbid psychopathology in youths with BD and present in psychiatrically healthy at-risk youths.
Conclusions |
Increased ISV-RT may be a risk marker for BD. Further research is needed to investigate the neural and genetic underpinnings of this deficit, as well as the specificity of the finding to BD. J. Am. Acad. Child Adolesc. Psychiatry, 2009;48(6):628-635.
Le texte complet de cet article est disponible en PDF.Key Words : bipolar disorder, sustained attention, endophenotype
Plan
| Dr. Brotman and Dr. Rooney contributed equally to this article. This article was reviewed under and accepted by Ad Hoc Editor David R. Rosenberg, M.D. All authors were with the Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services at the time the research was conducted. Ms. Rooney is with the University of Pennsylvania School of Medicine. Ms. Skup is with the Department of Biostatistics, Yale University School of Public Health. Funding support for this work was provided by the Intramural Research Program of the National Institute of Mental Health. Funding support for Melissa H. Rooney was provided through the Clinical Research Training Program, a public-private partnership supported jointly by the National Institutes of Health (NIH) and Pfizer (via a grant to the Foundation for NIH from Pfizer). The authors thank the children and families who made this study possible, along with the members of the Section on Bipolar Spectrum Disorders at the National Institute of Mental Health. The authors also thank Robert M. Bilder, Ph.D., ABPP-CN, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at University of California at Los Angeles, for statistical support. |
Vol 48 - N° 6
P. 628-635 - juin 2009 Retour au numéro
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