Low-dose naloxone does not improve morphine-induced nausea, vomiting, or pruritus - 21/08/11
, Jennifer Provataris, MD b, John Coffey, MD b, Polly Bijur, PhD b, E. John Gallagher, MD bAbstract |
Objective |
We tested the hypothesis that low-dose naloxone delivered with intravenous (IV) bolus morphine to emergency department patients in pain would reduce nausea.
Methods |
Randomized, double-blind, placebo-controlled trial. Patients receiving 0.10 mg/kg morphine IV bolus rated pain, nausea, and pruritus on 100-mm visual analog scales at enrollment and 20 minutes. Patients were randomized to 0.25 μg/kg naloxone or equal volume placebo administered with IV morphine.
Results |
One hundred thirty-one enrolled, 99 (76%) treated according to protocol with sufficient data for analysis. At 20 minutes the difference between groups (naloxone-placebo) was 1 mm (95% CI [confidence interval], −9 to 11) for nausea, 1 mm (95% CI, −3 to 3) for pruritus, 4% (95% CI, −1 to 9) for vomiting, and 0% (95% CI, −5 to 5) for rescue antiemetics. Pain was significantly reduced in both groups.
Conclusion |
Addition of 0.25 μg/kg naloxone to bolus morphine does not improve nausea, pruritus, vomiting, or reduce use of rescue antiemetics when administered to emergency department patients in pain.
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| ☆ | Previously presented at the SAEM meeting 2003, [Provataris J, Greenwald PW, Coffey J, Bijur P, Gallagher EJ. Low-dose naloxone does not improve nausea and pruritus associated with bolus IV morphine administration. Acad. Emerg. Med. 2003;10(5):470]. |
Vol 23 - N° 1
P. 35-39 - janvier 2005 Retour au numéro
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