Changes in Prostate-specific Antigen Levels and Prostate Volume in Octogenarian Men: Community-based Study - 22/08/11
, Byung Kyu Han b, Seong Jin Jeong b, Sung Kyu Hong b, Sang Eun Lee b
Reprint requests: Seok-Soo Byun, M.D., Ph.D., Department of Urology, Seoul National University, Bundang Hospital, 300, Gumi-dong, Bundang-gu, Seongnam. Gyunggido 463-707 KoreaRésumé |
Objectives |
To examine the change in prostate-specific antigen (PSA) levels and prostate volume (PV) in octogenarian men compared with those in septuagenarian men and evaluate the possibility of PSA as a surrogate marker for PV in octogenarian men.
Methods |
A total of 441 men were recruited from whom random and selected oldest-old samples (age ≥85 years) from the Korean Longitudinal Study on Health and Aging, which was a population-based, prospective cohort study on health, aging, and common geriatric diseases of Koreans ≥65 years old. Men in their 70s (n = 136, 70-79 years) and 80s (n = 125, 80-89 years) were included. The PV was measured by transrectal ultrasonography, and the PSA level was determined using immunoradioassay.
Results |
No significant differences were found in the serum PSA levels between the men in their 70s and 80s (P = .128). However, the 95th percentile of the serum PSA level was 5.23 and 6.60 ng/mL in those in their 70s and 80s, respectively. The men in their 80s had a greater total PV and transitional volume than did men in their 70s (P = .026 and P = .009, respectively). The PV and PSA level correlated with age (P = .034), and the increase in PV stratified by PSA was statistically significant (P < .0001).
Conclusions |
Although the PV had increased steadily in octogenarian men, the serum PSA level of men in their 80s did not show a significant difference compared with men in their 70s. We suggest that PSA is a good surrogate marker for PV, even in octogenarian men.
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| This work was supported by an Independent Research Grant from Pfizer Global Pharmaceuticals (grant 06-05-039) and by the Developing Seongnam Health Promotion Program for the Elderly from the Seongnam City Government in the Republic of Korea (grant 800-20050211). |
Vol 73 - N° 6
P. 1270-1273 - juin 2009 Retour au numéro
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