Nerve growth factor and chronic prostatitis/chronic pelvic pain syndrome - 01/09/11

Doi : 10.1016/S0090-4295(01)01597-7

Lauri J Miller ^a, Kateri A Fischer ^a, Sandra J Goralnick ^a, Mark Litt ^c, Joseph A Burleson ^d, Peter Albertsen ^b, Donald L Kreutzer ⁎, ^a,^b
^a Department of Pathology, University of Connecticut School of Medicine and School of Dental Medicine, Farmington, Connecticut, USA
^b Department of Surgery, University of Connecticut School of Medicine and School of Dental Medicine, Farmington, Connecticut, USA
^c Department of Behavioral Sciences and Community Health, University of Connecticut School of Medicine and School of Dental Medicine, Farmington, Connecticut, USA
^d Department of Community Medicine and Healthcare, University of Connecticut School of Medicine and School of Dental Medicine, Farmington, Connecticut, USA

^*Reprint requests: Donald L. Kreutzer, Ph.D., Departments of Pathology and Surgery, University of Connecticut School of Medicine, Farmington, CT 06030 USA

Abstract

Objectives. To investigate whether the pain experienced by patients with chronic prostatitis/chronic pelvic pain syndrome (CPPS) may be related to the expression of nerve growth factor (NGF), induced by inflammation and tissue injury experienced as a result of chronic inflammation. CPPS is a disease of unknown pathogenesis.

Methods. We measured the levels of NGF and the pro-inflammatory cytokine interleukin (IL)-6 and compared these with the levels of IL-8, interferon-gamma, IL-2, and IL-10 in the seminal plasma of 31 patients with CPPS and 14 controls using enzyme-linked immunosorbent assay technology. Results were correlated with health-related quality of life as measured by the multidimensional pain inventory, the McGill pain questionnaire, and the International Prostate Symptom Score.

Results. The cytokines analyzed were detectable in the seminal plasma from the patients with CPPS and controls. NGF correlated directly with pain severity (P <0.01) and IL-10 levels (P <0.04), and IL-6 correlated inversely with pain severity (P <0.03).

Conclusions. These results suggest that NGF and cytokines that regulate inflammation (IL-6 and IL-10) may play a role in the pain symptoms experienced by patients with CPPS.

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Plan

Material and methods

Patient populations

Specimen collection and storage

Cytokine quantification and analysis

Quality-of-life measures

Statistical analysis

Results

Cytokine levels in seminal plasma

Correlation of cytokines in seminal plasma of patients with CPPS

Correlations of NGF levels in seminal plasma with pain and quality-of-life measures

Correlation of IL-6 levels in seminal plasma with pain and quality-of-life measures

Correlations of IL-10 levels in seminal plasma with pain and quality-of-life measures

Comment

Conclusions

These studies were supported in part by grant DK-52718 from the National Institutes of Health.

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Vol 59 - N° 4

P. 603-608 - avril 2002 Retour au numéro

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Nerve growth factor and chronic prostatitis/chronic pelvic pain syndrome - 01/09/11

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