Peripheral Muscle Dysfunction in Chronic Obstructive Pulmonary Disease - 05/09/11
Résumé |
As their life expectancy has been prolonged with improved medical care, patients with chronic obstructive pulmonary disease (COPD) frequently develop systemic complications of their disease. These complications include osteoporosis, depression, and peripheral muscle dysfunction2 characterized by atrophy, weakness, and low oxidative capacity. These muscle changes have been associated with exercise intolerance,44 poor quality of life115 and reduced survival,108, 127 which occur independently of the impairment in lung function. Physicians dealing with patients with advanced COPD face the challenge of finding innovative ways to improve their patients' level of function despite the irreversible impairment of the primarily diseased organ. In this article, the evidence for peripheral muscle dysfunction in patients with COPD and the possible clinical implications of this problem are discussed. The available therapeutic options for improving peripheral muscle function are also considered.
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| Address reprint requests to François Maltais, MD, Centre de Pneumologie, Hôpital Laval, Institut Universitaire de Cardiologie, et de Pneumologie de l'Université Laval, 2725 Chemin Ste-Foy, Québec, Québec, Canada, G1V 4G5 This work was supported in part by the “Fonds de la recherche en santé du Québec,” Québec, and by “la fondation JD Bégin, Université Laval,” Ste-Foy, Québec, Canada. |
Vol 21 - N° 4
P. 665-677 - décembre 2000 Retour au numéro
Article précédent
- Advances in Radiologic Assessment of Chronic Obstructive Pulmonary Disease
- Joanne R. Cleverley, Nestor L. Müller
- Respiratory Muscle Function and Drive in Chronic Obstructive Pulmonary Disease
- Eric Marchand, Marc Decramer
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