Improving cystine stone therapy: an in vitro study of dissolution - 05/09/11
Abstract |
Objectives. To perform an in vitro study analyzing the possibilities in therapeutic strategies for an effective treatment of cystine stones.
Methods. Artificial stones made of cystine [Bon(n)-Stones] with a ball-shaped size of 0.9 cm in diameter were used. Chemolysis of artificial cystine stones with different solvents (artificial urine, physiologic sodium chloride solution, acetylcysteine, tris-(hydroxymethylene)-aminomethane [THAM], and combinations of these) was investigated. An experimental arrangement with computer-assisted online measurement of data simulating the physiologic conditions in the upper urinary tract at varying pH values was used.
Results. All solutions showed a statistical improvement in the solubility of cystine stones compared with artificial urine and physiologic sodium chloride solution. The combination of THAM (pH 10) and 2% acetylcysteine was most effective (13.91 ± 1.73 mg/hr) and demonstrated a 41-fold higher ability to dissolve cystine calculi compared with artificial urine.
Conclusions. Our data indicate that local chemolysis with special solutions is an effective treatment modality in cystine stone therapy.
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Vol 55 - N° 1
P. 17-21 - janvier 2000 Retour au numéro
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