Combined effect of dorzolamide and latanoprost on the rate of aqueous humor flow - 09/09/11
Abstract |
PURPOSE: To determine whether latanoprost, an ocular hypotensive agent believed to enhance uveoscleral outflow of aqueous humor, augments the aqueous-suppressing effect of dorzolamide, a topical carbonic anhydrase inhibitor.
METHODS: Twenty-four normal subjects underwent measurement of aqueous humor flow by fluorophotometry to determine the flow with placebo, with dorzolamide, and with a combination of dorzolamide and latanoprost.
RESULTS: The flow of aqueous humor was suppressed 13% by dorzolamide but not by latanoprost. Latanoprost did not augment the effect of dorzolamide on aqueous humor flow; latanoprost and dorzolamide had additive ocular hypotensive effects.
CONCLUSIONS: The uveoscleral flow effect of latanoprost does not improve the aqueous-suppressing effect of dorzolamide, but the two drugs have additive ocular hypotensive effects.
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 | Supported in part by grant EY 00634 from the National Institutes of Health, Bethesda, Maryland (Dr Brubaker); an unrestricted grant from Research to Prevent Blindness, Inc, New York, New York; and the Mayo Foundation, Rochester, Minnesota. |
Vol 126 - N° 2
P. 191-196 - août 1998 Retour au numéro
Article précédent
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- Paul Y Chung, Joel S Schuman, Peter A Netland, Rhea A Lloyd-Muhammad, Deborah S Jacobs
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- D. Barash, N. Goldenberg-Cohen, D. Tzadok, T. Lifshitz, Yuval Yassur, Dov Weinberger
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