Volumétrie de l’ischémie cérébrale en IRM de diffusion et déficit fonctionnel secondaire après thrombolyse intraveineuse - 15/05/12
, M.-P. Boncoeur-Martel a, A. Maubon a, C. Mounayer a, P. Couratier c, A. Labrunie d, J.-F. Le Bas e
Corresponding author. Unité d’IRM, CHU de Grenoble, BP 217, 38043 Grenoble cedex 9, France.
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Summary |
Background |
This study’s purpose was to demonstrate a relationship between growth of stroke volume measured on Diffusion-Weighted MRI (DWI) at admission (baseline) and 24hours later (follow-up) and functional outcome at 90 days evaluated by the modified Rankin Scale (mRS).
Methods |
DWI infarct volumes were calculated, using an Analyze Software. Clinical outcomes were assessed at 90 days by the mRS. Univariate regression analysis was performed to assess the relationship between changes in DWI lesion volume and mRS less or equal to 1.
Results |
Sixty-nine cases had serial DWI scans with a measurable lesion at baseline and follow-up. The median baseline National Institutes of Health Stroke Scale (NIHSS) was 10, 5 and 7 at 24hours. At 90 days, the proportion of patients with Rankin less or equal to 1 was 51.7%. The average baseline volume was 19.7cm3 and average follow-up volume was 46.1cm3. For each 10cm3 of growth in DWI infarct volume, the odds ratio for a mRS less or equal to 1 was 10,1 (IC 95%, 3–33.9).
Conclusion |
The results of this study provide evidence of a significant inverse relationship between infarct growth measured by DWI and good functional clinical outcome at 90 days.
Le texte complet de cet article est disponible en PDF.Keywords : Cerebral ischemia, Diffusion-Weighted Imaging lesion volume, Stroke outcome, Prognosis
Plan
Vol 39 - N° 2
P. 97-103 - mai 2012 Retour au numéro
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