Prediction score for effective bleeding control using recombinant activated factor VII in perioperative nonhemophilic patients - 17/08/13
, Edward B. McNeil, M.Sc. c, Alan F. Geater, Ph.D. c, Thavat Chanchayanon, M.D. a, Burapat Sangthong, M.D. d, Voravit Chittithavorn, M.D. eAbstract |
Background |
Although there has been growing evidence from off-label use of recombinant activated factor VII (rFVIIa) in surgical bleeding, there is limited information on prediction scores.
Methods |
A retrospective study was conducted from 2004 to 2009. The primary outcome was efficacy of bleeding control. Multivariate logistic regression was performed to develop a new prediction score for success of rFVIIa.
Results |
A total of 320 bleeding episodes from 243 nonhemophilic patients who underwent surgery were analyzed. Effective bleeding control was demonstrated in 153 patients. The overall in-hospital mortality rate was 40%. Multivariate analysis identified 4 independent predictors for effective bleeding control: timing of rFVIIa administration, intraoperative blood loss, postoperative international normalization ratio values, and total units of platelets transfused. A rFVIIa success prediction score was developed.
Conclusions |
The use of this new prediction score may support decision making by identifying patients with a high probability of obtaining effective bleeding control from rFVIIa therapy.
Le texte complet de cet article est disponible en PDF.Keywords : Recombinant activated factor VII, Off-label, Surgery, Mortality, Transfusion, Blood loss
Plan
| This study was supported by a grant from the Faculty of Medicine, Prince of Songkla University. |
|
| Conflicts of interest: None declared. |
Vol 206 - N° 3
P. 326-332 - septembre 2013 Retour au numéro
Article précédent
- Single incision vs conventional laparoscopic anterior resection for sigmoid colon cancer: a case-matched study
- Seung-Jin Kwag, Jun-Gi Kim, Seong-Taek Oh, Won-Kyung Kang
- Partial stomach-partitioning gastrojejunostomy and the success of this procedure in terms of palliation
- Rodrigo Arrangoiz, Pavlos Papavasiliou, Smit Singla, Veeraiah Siripurapu, Tianyu Li, James C. Watson, John P. Hoffman, Jeffrey M. Farma
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?