Ideal lag time from ovulation to oocyte aspiration using a GnRH agonist trigger - 20/08/21
, Allen Khakshooy a, 1 , Joshua Simons a, c , Amir Weiss a, d , Joel Geslevich d , Shlomit Goldman d , Shira Baram d , Simon Nothman a, d , Ronit Beck-Fruchter d Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Background |
In ART, oocyte maturation (M2) and ovulation is stimulated by a hormonal trigger. For maturation to occur, sufficient “lag time” must elapse between the trigger and aspiration, ranging from 32 to 38 hours. Premature aspiration can result in poor yields; late aspiration risks spontaneous ovulation.
Aim |
Our study examines optimal lag time using a GnRH antagonist protocol and GnRH agonist trigger for ICSI.
Methods and Materials |
We analyzed data from 220 women undergoing GnRH antagonist protocol using a GnRH agonist trigger for ICSI at our clinic between 02/2012−03/2018. Patients were divided into 4 groups based on lag time: 34.00–34.99 hours (n = 32), 35.00–35.99 hours (n = 113), 36.00–36.99 hours (n = 57) and 37.00 h or more (n = 18).
Analyses were performed with the Kruskal-Wallis test, Chi-Square, and Spearman’s rho correlation.
Results |
A positive correlation was found for the number of M2 oocytes aspirated and lag time (ρ = 0.138, p = 0.04) and for the total number of oocytes aspirated and lag time, (ρ = 0.174, p = 0.01). No correlation was found between the proportion of M2 oocytes aspirated and lag time (p = 0.217).
The third group (36 h) had significantly more M2 oocytes aspirated than the second group (35 h) (12.4 ± 7.1 vs 9.4 ± 6.2; p = 0.039). The four groups did not differ for the proportion of mature M2 oocytes (H = 2.453, p = 0.484). The four groups differed in the frequency of live births per fresh embryos transferred (χ2 = 9.364, p = 0.025).
Conclusion |
Our study identified a positive correlation between lag time and both the number of M2 oocytes and the total number of oocytes aspirated-factors which lead to an increased rate of successful pregnancies. Further research is necessary.
Le texte complet de cet article est disponible en PDF.Keywords : Lag time, GnRH antagonist protocol, GnRH agonist trigger, Triptorelin acetate, ART, M2 oocytes
Plan
Vol 50 - N° 7
Article 102055- septembre 2021 Retour au numéro
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