MiR-661 contributed to cell proliferation of human ovarian cancer cells by repressing INPP5J expression - 12/10/15
, Jing Yuan b, Yuzhi Wang a, Cuiping Gong a, Yudou Xie a, Hong Li cBenvenuto su EM|consulte, il riferimento dei professionisti della salute.
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Abstract |
Accumulating evidence has emerged important roles for microRNAs (miRNAs) participating in oncogenesis and growth of various cancers. We hypothesized that miR-661 played an important role in cell growth of ovarian cancer. Here, we found miR-661 was upregulated in human ovarian cancer cell lines and clinical tumor tissues. Our results revealed that miR-661 directly targeted INPP5J, thereby acting as tumor promoter in ovarian cancer cells by blocking cell proliferation. Importantly, we identified miR-661 as a positive regulator of INPP5J-induced AKT pathway. Taken together, our study sheds light onto the role of miR-661 as tumor promoter by targeting the INPP5J gene, and then promoting cell proliferation of ovarian cancer.
Il testo completo di questo articolo è disponibile in PDF.Keywords : miR-661, Human ovarian cancer, INPP5J, Cell proliferation
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Vol 75
P. 123-128 - ottobre 2015 Ritorno al numero
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