Association between hip morphology and prevalence, clinical severity and progression of hip osteoarthritis over 3 years: The knee and hip osteoarthritis long-term assessment cohort results - 06/06/16

Doi : 10.1016/j.jbspin.2015.09.005

Benjamin Bouyer ^a,^b, Bernard Mazieres ^c, Francis Guillemin ^d,^e,^f, Ronan Bouttier ^g, Bruno Fautrel ^h,ⁱ, Johanne Morvan ^j,^k, Jacques Pouchot ^a,^l, Anne-Christine Rat ^d,^e,^f, Christian H. Roux ^m, Evelyne Verrouil ^c, Alain Saraux ^n,^o, Joël Coste ^a,^b,^⁎
for the KHOALA cohort study group
^a EA 4360 Apemac, University Paris-Descartes, University of Lorraine, 75013 Paris, France
^b Biostatistics and Epidemiology Unit, Hôtel-Dieu, Assistance publique–Hôpitaux de Paris, 1, place du Parvis-Notre-Dame, 75004 Paris, France
^c Rheumatology centre, Purpan University Hospital, 31000 Toulouse, France
^d Faculty of medicine, School of public health, CHU de Brabois, 54500 Vandœuvre-lès-Nancy, France
^e CIC-EC CIE6, Inserm, 54500 Vandœuvre-lès-Nancy, France
^f Rheumatology department, CHU de Brabois, 54500 Vandœuvre-lès-Nancy, France
^g Radiology department, Cavale-Blanche University Hospital, 29200 Brest, France
^h Rheumatology department, groupe hospitalier Pitié-Salpêtrière, Assistance publique–Hôpitaux de Paris, 75013 Paris, France
ⁱ GRC-08-EEMOIS, University Paris 6 Pierre-et-Marie-Curie, 75005 Paris, France
^j Medicine department, Laennec hospital, 29000 Quimper, France
^k Rheumatology department, Cavale-Blanche University Hospital, 29200 Brest, France
^l Department of internal medicine, hôpital européen Georges-Pompidou, Assistance publique–Hôpitaux de Paris, 75015 Paris, France
^m Rheumatology department, Academic Hospital l’Archet 1, 06200 Nice, France
ⁿ EA 2216, University Bretagne-Occidentale, 29200 Brest, France
^o Faculty of Medicine, Paul-Sabatier University, 31000 Toulouse, France

^⁎Corresponding author. Biostatistics and Epidemiology Unit, Hôtel-Dieu, Assistance publique–Hôpitaux de Paris, 1, place du Parvis-Notre-Dame, 75004 Paris, France.

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Abstract

Objective

To assess the effects of variations in hip morphology on prevalence, clinical severity and progression of hip osteoarthritis.

Methods

From 2007 to 2009, we conducted a study of 242 patients aged between 40 and 75 years with symptomatic lower limb osteoarthritis, as part of a population-based osteoarthritis cohort study in France. Standard radiographs of both hips were obtained at baseline and at three years. The progression of hip osteoarthritis was evaluated according to the radiological Kellgren-Lawrence score (KL) and clinical severity from the scores on a Visual Analogic Scale (VAS) for pain recorded yearly. Five measures were used to describe hip morphology: centre edge angle, acetabular index (AI), vertical centre anterior angle, acetabular depth and neck-shaft angle.

Results

Of the 484 hips studied, 205 (42%) showed osteoarthritis at baseline and 16 (11 right and 5 left) underwent joint replacement during the follow-up. AI was the morphological measure most consistently and strongly associated with radiographic osteoarthritis at baseline (odds-ratio=1.05, 95% CI: 1.01–1.08 per degree of angle change), clinical severity (correlation coefficient with VAS during 3 years=0.15, P=0.004), radiological progression (odds-ratio=1.05, 95% CI: 1.00–1.10 per degree) and joint replacement (hazard ratio=1.18, 95% CI: 1.07–1.29 per degree).

Conclusions

Acetabular obliquity and especially AI is strongly, and likely causally, associated with the existence, severity and progression of hip osteoarthritis.

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Keywords : Osteoarthritis, Hip, Hip morphology, Cohort studies

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Follow-up and characteristics of the patients

Association between morphological parameters and OA at baseline

Association between morphological parameters and clinical severity of OA

Association between morphological parameters and radiological progression

Association between morphological parameters and implantation of joint prosthesis

Threshold

Analysis by side

Discussion

Disclosure of interest

Esportazione

Vol 83 - N° 4

P. 432-438 - luglio 2016 Ritorno al numero

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Association between hip morphology and prevalence, clinical severity and progression of hip osteoarthritis over 3 years: The knee and hip osteoarthritis long-term assessment cohort results - 06/06/16

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