Pyostomatitis vegetans (PSV)-pyodermatitis vegetans (PDV): A clinicopathologic study of 7 cases at a tertiary referral center - 17/08/16
Abstract |
Background |
Pyostomatitis vegetans (PSV)-pyodermatitis vegetans (PDV) is a rare inflammatory mucocutaneous disease associated with inflammatory bowel disease.
Objective |
We sought to evaluate the clinicopathologic findings of PSV-PDV in a series of 7 patients.
Methods |
We conducted a retrospective review of all cases of PSV-PDV at the Mayo Clinic from 1995 to 2014.
Results |
Seven patients with PSV-PDV were included, and all had inflammatory bowel disease. Three had Crohn's disease and 4 had ulcerative colitis. Three patients had peripheral blood eosinophilia. Two had concomitant pyoderma gangrenosum in which pyoderma gangrenosum lesions were recalcitrant to therapy. Primary sclerosing cholangitis was seen in 3 patients. Two patients had direct and 3 had indirect immunofluorescence findings. Tissue eosinophilia was seen in the majority of mucosal and cutaneous lesions.
Limitations |
Limited sample size and retrospective study design are limitations.
Conclusions |
PSV-PDV is associated with inflammatory bowel disease and primary sclerosing cholangitis and may precede gastrointestinal symptoms. Immunofluorescence findings in select PSV-PDV cases may indicate possible overlap with autoimmune bullous disease. Tissue eosinophilia may be helpful in distinguishing PSV-PDV from pyoderma gangrenosum. Strict control of bowel disease and close monitoring of patients with subclinical disease is warranted.
Il testo completo di questo articolo è disponibile in PDF.Key words : Crohn's disease, inflammatory bowel disease, pemphigus, primary sclerosing cholangitis, pyoderma gangrenosum, pyodermatitis, pyostomatitis, ulcerative colitis, vegetans
Abbreviations used : BMZ, DIF, IBD, PBE, PDV, PG, PSC, PSV, UC
Mappa
| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 75 - N° 3
P. 578-584 - settembre 2016 Ritorno al numero
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