Evidence for physiological and pathological roles for sensory nerves in the microvasculature and skin - 03/01/17
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Abstract |
This review highlights the progress from the initial finding of neurogenic inflammation up to the most recent development in the field of sensory nerves research, focusing on their roles in the microvasculature and the skin. Recent discovery of Transient Receptor Potential (TRP) channels highlight their important roles in detecting a range of environmental stimuli, including chemical and temperature. This provides us novel mechanisms for driving neurogenic inflammation upstream of neuropeptide release in addition to promising potential therapeutic targets in various diseases, including pain, itching and skin inflammation.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Sensory nerves, Transient receptor potential channels, Neuropeptides, Skin inflammation, Peripheral vasculature
Abbreviations : ATP, CFA, CGRP, CLR, CQ, DRG, GRPR, IL, IMQ, KO, Mrgpr, NADPH, NGF, NK1, nNOS, NO, PAR, PGE2, RAMP, RCP, ROS, SP, TNF-α, TRP, TRPA1, TRPV1, TSLP, WT, 4-ONE
Mappa
Vol 64 - N° 4
P. 195-201 - ottobre 2016 Ritorno al numero
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