Poloxamer surface modified trimethyl chitosan nanoparticles for the effective delivery of methotrexate in osteosarcoma - 04/05/17
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
| pagine | 8 |
| Iconografia | 7 |
| Video | 0 |
| Altro | 0 |
Abstract |
The present work is an effort to explore the poloxamer-modified trimethyl chitosan (TMC) encapsulated MTX for osteosarcoma treatment in order to improve the therapeutic efficacy and minimize severe toxicity associated with the clinical usage of MTX. The methotrexate-loaded pluronic-chitosan nanoparticles (MTCN) was nanosized and exhibited a controlled release of drug from the carrier system. The MTCN showed higher accumulation in cell cytoplasm region evident by the high red fluorescence indicating its uptake through energy-dependent endocytosis process. MTCN exhibited the increased cytotoxicity in MG63 cells compared free MTX due to its enhanced cellular uptake. Especially, MTCN exhibited a superior apoptosis effect with bright chromatin condensation and nuclear fragmentation was observed and showed remarkably higher apoptosis (∼48%) compared to that of free drug. The results of this investigation clearly demonstrate that the poloxamer-modified trimethyl chitosan (TMC) seems to have a great potential as a drug carrier in cancer chemotherapy. The present research work offers immense scope for further exploitation of poloxamer-modified trimethyl chitosan (TMC) in future for the development of nanoparticulate drug delivery system for cancer chemotherapy.
Il testo completo di questo articolo è disponibile in PDF.Keyword : Osteosarcoma, Methotrexate, Trimethyl chitosan, Nanoparticles, Anticancer
Mappa
Vol 90
P. 872-879 - giugno 2017 Ritorno al numero
Articolo precedente
- Does propolis have any effect on non-alcoholic fatty liver disease?
- Kemal Kismet, Cigdem Ozcan, Serdar Kuru, Omur Gencay Celemli, Pinar Celepli, Mehmet Senes, Tuncay Guclu, Kadriye Sorkun, Sema Hucumenoglu, Tanju Besler
- The therapeutic effect of nano-encapsulated and nano-emulsion forms of carvacrol on experimental liver fibrosis
- Jihan Hussein, Mona El-Banna, Khaled F. Mahmoud, Safaa Morsy, Yasmin Abdel Latif, Dalia Medhat, Eman Refaat, Abdel Razik Farrag, Sherien M. El-Daly
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?