Does lymph node status influence adjuvant therapy decision-making in women 70 years of age or older with clinically node negative hormone receptor positive breast cancer? - 22/11/17
, Nina Horowitz a, Tara Sanft b, Lynn D. Wilson c, Andrea Silber b, Brigid Killelea a, Meena S. Moran c, Michael P. DiGiovanna b, Erin Hofstatter b, Gina Chung b, Lajos Pusztai b, Donald R. Lannin aAbstract |
Background |
Women ≥70 years old with clinically (c) lymph node (LN) negative (−), hormone receptor (HR) positive (+) breast cancer are recommended not to be routinely staged with a sentinel LN biopsy. We sought to determine how this affects adjuvant decision-making.
Methods |
Statistical analyses were performed to determine the association of LN evaluation with adjuvant chemotherapy and radiation therapy in cLN-, HR + breast cancer patients in the National Cancer Database.
Results |
Between 2004 and 2013, there were 193,728 patients aged 70–90 with cLN-, HR + breast cancer; 15.0% were LN+. LN + patients were more likely to receive chemotherapy (28.3% vs. 5.5%, p < 0.001), hormonal therapy (83.6% vs. 71.4%, p < 0.001), post-lumpectomy radiation therapy (81.4% vs. 73.6%, p < 0.001) and post-mastectomy radiation therapy (30.3% vs. 5.1%, p < 0.001).
Conclusion |
15% of patients aged 70–90 will be LN+. These patients more frequently receive systemic and radiation therapy. LN status may affect treatment in these patients.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Sentinel node biopsy, Axilla, Breast cancer, Elderly, Adjuvant therapy
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Vol 214 - N° 6
P. 1082-1088 - dicembre 2017 Ritorno al numero
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- Discussion of: “Does lymph node status influence adjuvant therapy decision-making in women 70 years of age or older with clinically node negative hormone receptor positive breast cancer?”
- Anees B. Chagpar, Nina Horowitz, Tara Sanft, Lynn D. Wilson, Andrea Silber, Brigid Killelea, Meena S. Moran, Michael P. DiGiovanna, Erin Hofstatter, Gina Chung, Lajos Pusztai, Donald R. Lannin
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