Reference values for skin microanatomy: A systematic review and meta-analysis of ex vivo studies - 23/11/17

Doi : 10.1016/j.jaad.2017.06.009

Haoming Xu, BS ^a, Maira Fonseca, MD ^a, Zachary Wolner, BA ^a, Esther Chung, MD ^a, Xinyuan Wu, MD ^a, Shamir Geller, MD ^a, Stephen W. Dusza, DrPH ^a, Antonio P. DeRosa, MDS, MLIS, AHIP ^b, Ashfaq A. Marghoob, MD ^a, Klaus J. Busam, MD ^c, Allan C. Halpern, MD ^a, Michael A. Marchetti, MD ^a,^⁎
^a Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
^b Medical Library, Information Systems, Memorial Sloan Kettering Cancer Center, New York, New York
^c Dermatopathology Service, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York

^∗Correspondence to: Michael A. Marchetti, MD, Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 16 E 60th St, New York, NY 10022.Dermatology ServiceDepartment of MedicineMemorial Sloan Kettering Cancer Center16 E 60th StNew YorkNY10022

Abstract

Background

Few studies have characterized reference values of normal human skin microanatomy parameters.

Objective

To quantify histologic measurements of epidermal thickness, melanocyte density, hair follicle density, and eccrine gland density as a function of age and anatomic site.

Method

We searched the PubMed, Embase, Web of Science, and Cochrane databases for articles published through May 25, 2017. Two reviewers independently screened 2016 articles; 327 relevant articles and 151 additional articles found via forward or reference citations underwent full-text review by 1 of 4 reviewers for relevance, data extraction, and critical appraisal. Weighted averages, meta-analysis, and meta-regression were used in statistical analysis.

Results

A total of 56 articles were included; when all anatomic locations were used, the overall estimates for epidermal thickness, melanocyte density, hair follicle density, and eccrine gland density were 99.75 μm (95% confidence interval [CI], 83.25-116.25), 955.05 cells/mm² (95% CI. 880.89-1029.21), 1.40 hairs/mm² (95% CI. 0.91-1.89), and 1.28 glands/mm² (95% CI. 0.91-1.64), respectively.

Limitations

There was significant data heterogeneity across studies, possibly because of differences in histological techniques and absence of standardized microanatomy definitions.

Conclusions

We established summary estimates for normal human skin microanatomy parameters.

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Key words : eccrine gland density, epidermal thickness, hair follicle density, melanocyte density, normal-appearing skin, systematic review

Abbreviations used : CI, EGD, ET, GET, HFD, MD, SCT

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Methods

Literature search

Data abstraction

Skin microanatomy parameters and eligibility criteria

	Mr Xu, Dr Fonseca, and Mr Wolner contributed equally to this article.
	Supported in part through National Institutes of Health/National Cancer Institute Cancer Center Support Grant P30 CA008748.
	Conflicts of interest: None declared.
	Reprints not available from the authors.

Esportazione

Vol 77 - N° 6

P. 1133 - dicembre 2017 Ritorno al numero

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Reference values for skin microanatomy: A systematic review and meta-analysis of ex vivo studies - 23/11/17

Abstract

Background

Objective

Method

Results

Limitations

Conclusions

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