Prophylactic negative-pressure wound therapy after cesarean is associated with reduced risk of surgical site infection: a systematic review and meta-analysis - 28/02/18
, Ryan J. Kronen, BA a, 1, Laura E. Simon, MLIS b, Carolyn R.T. Stoll, MPH, MSW c, Graham A. Colditz, MD, DrPH a, d, Methodius G. Tuuli, MD, MPH eAbstract |
Objective |
The objective of the study was to assess the effect of prophylactic negative-pressure wound therapy on surgical site infections and other wound complications in women after cesarean delivery.
Data Sources |
We searched Ovid Medline, Embase, SCOPUS, Cochrane Database of Systematic Reviews, and ClinicalTrials.gov.
Study Eligibility Criteria |
We included randomized controlled trials and observational studies comparing prophylactic negative-pressure wound therapy with standard wound dressing for cesarean delivery.
Study Appraisal and Synthesis Methods |
The primary outcome was surgical site infection after cesarean delivery. Secondary outcomes were composite wound complications, wound dehiscence, wound seroma, endometritis, and hospital readmission. Heterogeneity was assessed using Higgin’s I2. Relative risks with 95% confidence intervals were calculated using random-effects models.
Results |
Six randomized controlled trials and 3 cohort studies in high-risk mostly obese women met inclusion criteria and were included in the meta-analysis. Six were full-text articles, 2 published abstracts, and 1 report of trial results in ClinicalTrials.gov. Studies were also heterogeneous in the patients included and type of negative-pressure wound therapy device. The risk of surgical site infection was significantly lower with the use of prophylactic negative-pressure wound therapy compared with standard wound dressing (7 studies: pooled risk ratio, 0.45; 95% confidence interval, 0.31–0.66; adjusted risk ratio, –6.0%, 95% confidence interval, –10.0% to –3.0%; number needed to treat, 17, 95% confidence interval, 10–34). There was no evidence of significant statistical heterogeneity (I2 = 9.9%) or publication bias (Egger P = .532). Of the secondary outcomes, only composite wound complications were significantly reduced in patients receiving prophylactic negative-pressure wound therapy compared with standard dressing (9 studies: pooled risk ratio, 0.68, 95% confidence interval, 0.49–0.94).
Conclusion |
Studies on the effectiveness of prophylactic negative-pressure wound therapy at cesarean delivery are heterogeneous but suggest a reduction in surgical site infection and overall wound complications. Larger definitive trials are needed to clarify the clinical utility of prophylactic negative-pressure wound therapy after cesarean delivery.
Il testo completo di questo articolo è disponibile in PDF.Key words : antibiotics, cesarean delivery, dehiscence, endometritis, hospital readmission, meta-analysis, prophylactic negative-pressure wound therapy, seroma, surgical site infection
Mappa
| The views expressed herein are those of the authors and do not necessarily represent the official view of the National Institutes of Health. |
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| Dr Colditz is supported in part by the Foundation for Barnes Jewish Hospital. Dr. Tuuli is supported by National Institutes of Health grants U01 (U01HD077384-03) and R01 (1R01HD086007-01). Dr Tuuli received supplemental research grant funding from Acelity, manufacturers of Prevena. |
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| The authors report no potential conflict of interest. |
Vol 218 - N° 2
P. 200 - febbraio 2018 Ritorno al numero
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