A review of FGF signaling in palate development - 29/05/18
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Highlights |
• | FGF signaling is critical throughout the process of palatogenesis especially in the outgrowth of palatal shelves. |
• | The important roles of interaction between Fgf family and other signaling pathways during palatogenesis. |
• | Nicotine, chlorcyclizine, TCDD, dexamethasone and retinoids could induce cleft palate via FGF signaling and other factors. |
Abstract |
The fibroblast growth factors (FGFs) play a critical role during palatogenesis by mediating a variety of cellular responses. Extensive epidemiological and genetic studies over several decades in humans have revealed members of the FGF family function as candidate genes for syndromic and nonsyndromic cleft lip and cleft palate. The findings that FGFs signaling work delicately in the development of palate have been confirmed in mice carrying targeted mutations. Here we try to review recent progress toward a detailed understanding of FGF signaling including FGF7, FGF8, FGF9, FGF10, FGF18 and their receptors FGFR1, FGFR2 in palate development studies and discuss how they interact with other factors on the basis of animal studies regarding cleft palate.
Il testo completo di questo articolo è disponibile in PDF.Keywords : FGF signaling, Cleft palate, Palatogenesis, Teratogens
Mappa
Vol 103
P. 240-247 - luglio 2018 Ritorno al numero
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