Modulation of hyperglycemia and dyslipidemia in experimental type 2 diabetes by gallic acid and p-coumaric acid: The role of adipocytokines and PPARγ - 11/07/18
, Sanaa M. Abd El-Twab, Ahmed I. Yousef, Eman S. Abdel Reheim, Mohamed B. AshourBenvenuto su EM|consulte, il riferimento dei professionisti della salute.
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Graphical abstract |
Highlights |
• | Gallic acid and p-coumaric acid ameliorate insulin shortage and insulin resistance. |
• | They also modulate adipocytokines secretion and upregulate PPAR γ mRNA expression. |
• | Thus, both agents attenuate hyperglycemia and dyslipidemia in diabetic rats. |
Abstract |
There are many indications that confirm the vital role of adipocytokines and PPARγ in diabetics. Hence, the current investigation aimed to study the modulatory effects of gallic acid and p-coumaric acid on adipocytokines secretion and PPARγ mRNA expression in type 2 diabetic rats. After induction of type 2 diabetes, diabetic rats were orally treated with 20 mg/kg body mass gallic acid and 40 mg/kg body mass p-coumaric acid for six weeks. Among treatment diabetic rats, glucose and glycosylated hemoglobin levels significantly declined in diabetic rats, while insulin level and body weight significantly increased as compared to control group. Gallic acid and p-coumaric acid markedly decreased the level of TNF-α and increased the levels of PPARγ mRNA and adiponectin. In addition, the tested agents improved markedly lipid profile parameters, cardiovascular indices 1 and 2 and anti-atherogenic index. In conclusion, gallic acid and p-coumaric acid exhibited marked antidiabetic action that could be mediated via modulation of TNF-α and adipocytokines secretions as well as upregulation of PPARγ mRNA expression.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Gallic acid, p-Coumaric acid, Type 2 diabetic rats, TNF-α, Adiponectin, PPARγ
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Vol 105
P. 1091-1097 - settembre 2018 Ritorno al numero
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