Tris-hydroxymethylaminomethane (THAM): An efficient organocatalyst in diversity-oriented and environmentally benign synthesis of spirochromenes - 17/09/18
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Abstract |
Tris-hydroxymethylaminomethane has been demonstrated to be an efficient organocatalyst in diversity-oriented synthesis of medicinally prevalent spirochromenes by one-pot, three-component reactions between isatins, malononitrile, and enolizable C-H acids like dimedone, 4-hydroxycoumarin, 4-hydroxy-N-methylquinolin-2-one, or in situ generated 2-methylpyrazolon-2-one. Biodegradability and extremely low cost of the catalyst are the noteworthy features of this chromatography-free protocol.
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Keywords : Multicomponent synthesis, Tris-hydroxymethylaminomethane, Organocatalysis, Spirochromenes, Green chemistry
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Vol 21 - N° 9
P. 814-821 - settembre 2018 Ritorno al numero
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