Presence of a functional TSH receptor on human erythrocytes - 22/03/08
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Abstract |
The presence of thyrotropin receptors (TSHR) has been reported in some extrathyroidal tissues but its physio-pathological role still remains unclear. TSH (seems to) affects the human erythrocytes Na+/K+-ATPase in vitro, however receptors on erythrocytes have not yet been described.
In this work the effect of recombinant human TSH (rhTSH) on sites number and activity of erythrocyte Na+/K+-ATPase was investigated in a group of thyroidectomized patient enrolled for rhTSH test. As detected by 3H-ouabain binding, rhTSH administration induced a significant increase in the number of sites (p=0.005) and in the Kd (p=0.006) of Na+/K+-ATPase. rhTSH did not induce significant difference in Na+/K+-ATPase activity measured by 86Rb uptake.
125I-TSH binding studies and Western blotting data showed the existence of TSHR in the erythrocytes of healthy donors.
In conclusion The TSH action on Na+/K+-ATPase of human erythrocytes can be explained by the presence of TSHR
Il testo completo di questo articolo è disponibile in PDF.Keywords : rhTSH, Na+/K+-ATPase, Red blood cell, TSH receptor
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Vol 61 - N° 8
P. 463-467 - settembre 2007 Ritorno al numero
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