Treatment of morphea with hydroxychloroquine: A retrospective review of 84 patients at Mayo Clinic, 1996-2013 - 16/05/19
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Abstract |
Background |
Few studies support treating morphea (localized scleroderma) with hydroxychloroquine.
Objective |
To assess the efficacy of hydroxychloroquine treatment of morphea.
Methods |
We conducted a retrospective study of 84 patients who had morphea and were treated with hydroxychloroquine monotherapy for at least 6 months at our institution from 1996 through 2013. The median times to initial and maximal responses were assessed.
Results |
Of the 84 patients (median age at diagnosis, 29.5 years), 65 (77.4%) were female, 36 (42.9%) had a complete response to hydroxychloroquine, 32 (38.1%) had a partial response greater than 50%, 10 (11.9%) had a partial response less than or equal to 50%, and 6 (7.1%) had no response. The median time to initial response was 4 months, and the median time to maximal response was 12 months. Ten patients (11.9%) experienced adverse effects from hydroxychloroquine; the most common adverse effect was nausea (6 patients).
Limitations |
Retrospective study.
Conclusions |
Hydroxychloroquine is a valuable treatment for morphea because of its high response rate and low rate of adverse effects; however, prospective studies are needed to determine its true efficacy.
Il testo completo di questo articolo è disponibile in PDF.Key words : antimalarial, connective tissue disease, en coup de sabre, hydroxychloroquine, localized scleroderma, morphea
Abbreviations used : CR, HCQ, NR, PR
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| Funding sources: None. |
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| Conflicts of interest: None disclosed. |
Vol 80 - N° 6
P. 1658-1663 - giugno 2019 Ritorno al numero
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