Chronic stress induces persistent low-grade inflammation - 26/09/19
, Camille G. Apple a , Kolenkode B. Kannan a , Zackary M. Funk b , Jessica M. Plazas c , Philip A. Efron a , Alicia M. Mohr a, ⁎ Abstract |
Introduction |
This study sought to determine if the systemic cytokine profile of rodents subjected to chronic restraint stress leads to persistent low-grade inflammation.
Methods |
Male Sprague-Dawley rats were subjected to restraint stress for a total of seven or fourteen days. Urine norepinephrine (NE), plasma interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP) were assessed with ELISA. Liver expression of IL-6 and TNF-α were assessed with real time PCR.
Results |
Chronic stress at 7 and 14 days sequentially increased plasma acute phase reactants (NE, IL-6, TNF-α, and CRP), liver IL-6 expression, hematopoietic progenitor cell mobilization, and decreased erythroid progenitor colony growth. Weight gain was reduced by chronic stress compared to each models’ naïve counterpart.
Conclusions |
Combining this model with trauma and sepsis models will allow evaluation of the contribution of persistent inflammation in disease progression and outcomes.
Il testo completo di questo articolo è disponibile in PDF.Highlights |
• | A daily restraint stress model can produce a low grade inflammatory state. |
• | Daily restraint stress increased norepinephrine and inflammatory cytokines. |
• | Daily restraint stress was associated with reduced weight gain. |
• | Adding stress to injury models can mirror the impact of the critical illness. |
Keywords : Inflammation, Stress, Norepinephrine, IL-6, C-reactive protein
Mappa
Vol 218 - N° 4
P. 677-683 - ottobre 2019 Ritorno al numero
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