Type A competitiveness traits correlate with downregulation of c-Fos expression in patients with type 1 diabetes - 14/11/19

Doi : 10.1016/j.diabet.2018.11.005

J.-C. Chauvet-Gélinier ^a,^d, A.-L. Mosca-Boidron ^h, C. Lemogne ^e,^f,^g, S. Ragot ^h, N. Forestier ^a, D. Callegarin ^h, C. Allard ^a, A. Rebaï ^a, B. Bouillet ^c,^d, E. Ponavoy ^a, I. Simoneau ^c,^d, J.-M. Petit ^c,^d, G. Bondolfi ⁱ, P. Callier ^h, B. Trojak ^a, B. Bonin ^a,^b, B. Vergès ^c,^d,^⁎
^a Psychiatry unit, department of neurosciences, university hospital, CHU de Le Bocage, Bâtiment Marion, 14, rue Gaffarel, 21000 Dijon, France
^b Laboratoire de psychopathologie et de psychologie médicale (IFR 100), université de Bourgogne-Franche-Comté, 21000 Bourgogne-Franche-ComtéFrance
^c Department of endocrinology and metabolic diseases, university hospital CHU de Le Bocage, 2, boulevard Maréchal de Lattre de Tassigny, 21000 Dijon, France
^d Inserm LNC-UMR 1231, 21000 Dijon, France
^e Université Paris Descartes, Sorbonne Paris Cité, faculté de médecine, 75006 Paris, France
^f AP–HP, hôpitaux universitaires Paris Ouest, service de psychiatrie et d’addictologie de l’adulte et du sujet âgé, 75015 Paris, France
^g Inserm, centre for psychiatry and neuroscience, U894, 21000 Paris, France
^h Laboratoire de génétique chromosomique et moléculaire, plateforme de biologie hospitalo-universitaire, CHU de le Bocage, Dijon, France
ⁱ Service de psychiatrie de liaison et d’intervention de crise, hôpitaux universitaires de Genève, Geneva, Switzerland

^⁎Corresponding author at: Department of endocrinology and metabolic diseases, university hospital CHU de Le Bocage, Inserm LNC-UMR, 2, boulevard Maréchal de Lattre de Tassigny, 21000 Dijon, France.Department of endocrinology and metabolic diseasesuniversity hospital CHU de Le BocageInserm LNC-UMR2, boulevard Maréchal de Lattre de TassignyDijon21000France

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Abstract

Aim

Type A personality has been associated with increased survival in people with type 1 diabetes (T1D). Systemic low-grade inflammation may play a critical role, as suggested in recent reports, although the links between the inflammatory circulating transcriptome and Type A remain unknown. This prompted our exploration of the potential associations between Type A personality and c-Fos gene expression, a candidate gene closely linked to inflammatory processes, in T1D.

Methods

Type A personality was assessed by Bortner questionnaire in patients with T1D, and two subscales – ‘speed’ and ‘competitiveness’ – were used to measure these specific dimensions of Type A. Expression of the c-Fos gene was assessed by a quantitative real-time polymerase chain reaction technique.

Results

This pilot study included 20 men with T1D. Multivariable analyses showed an independent inverse association between Type A competitiveness score and c-Fos expression, while a regression model adjusted for age, body mass index and HbA_1c levels revealed a significant inverse relationship between c-Fos transcripts and Type A competitiveness (P = 0.003).

Conclusion

This strong association between Type A competitiveness and reduced c-Fos expression is in line with recent data suggesting a psychobiological influence of the Type A profile in T1D via inflammatory pathways.

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Keywords : c-Fos, Competitiveness, Diabetes, Inflammation, Personality, Type A

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Clinical and biological measurements

Psychological measurements

Statistical analysis

Results

General characteristics

Association between c-Fos gene expression and Type A personality

Discussion

Conclusion

Funding

Disclosure of interest

Esportazione

Vol 45 - N° 6

P. 582-585 - dicembre 2019 Ritorno al numero

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Type A competitiveness traits correlate with downregulation of c-Fos expression in patients with type 1 diabetes - 14/11/19

Abstract

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Methods

Results

Conclusion

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