Indications of plasma exchanges in combination with intravenous immunoglobulins or therapeutic monoclonal antibodies. How to combine them? - 04/12/19

Doi : 10.1016/j.lpm.2019.10.006

Chiara Vendramin ^1,², Marie Scully ^1,^2,^3,^⁎
¹ University College London, Haemostasis Research Unit, London, United Kingdom
² University College London Hospital, Department of Haematology, London, United Kingdom
³ University College London Hospital, UCL Biomedical Research Centre, National Institute for Health Research Cardiometabolic Programme, London, United Kingdom

^⁎Marie Scully, University College London Hospital, Department of Haematology, 1st Floor, 51 Chenies Mews, London WC1E 6HX, United Kingdom.University College London Hospital, Department of Haematology1st Floor, 51 Chenies MewsLondon WC1E 6HXUnited Kingdom

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Summary

Plasma exchange (PEX) is a therapeutic procedure used to treat diseases caused by pathogenic antibodies or immune-complexes through the removal and the replacement of plasma. The frequency of complications and reactions associated with PEX are mild and of limited duration. In systemic autoimmune diseases and in a variety of other conditions, PEX might be use in association with intravenous immunoglobulin (IVIg) or therapeutic monoclonal antibodies for the management of acute or refractory patients to achieve a durable remission.

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