Optimal acquisition time to discriminate between breast cancer subtypes with contrast-enhanced cone-beam CT - 29/05/20
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
Articolo gratuito.
Si connetta per beneficiarne
Abstract |
Purpose |
To identify the optimal acquisition time to best discriminate between benign and malignant breast lesions on contrast-enhanced cone beam CT (CE-CBCT) and evaluate the potential of CE-CBCT to differentiate between breast cancer subtypes.
Material and method |
A total of 98 women with a mean age of 49±10 (SD) years (range: 29–77 years) with 100 BI-RADS 4 or 5 breast lesions were prospectively included. CE-CBCT images were obtained at 1- and 2-min after intravenous administration of iodinated contrast material. Contrast enhancement of breast lesions on CE-CBCT were evaluated and compared between different subtypes. Cut-off values for best discriminating between benign and malignant breast lesions with CE-CBCT were obtained from receiver operating characteristic curves.
Results |
Malignant breast lesions showed greater enhancement than benign ones at 1-min (67.28±39.79 [SD] HU vs. 42.27±40.31 [SD] HU, respectively; P=0.007) and 2-min (70.93±38.05 [SD] HU vs. 48.94±41.83 [SD] HU, respectively; P=0.016) after intravenous administration of contrast material. At 1-min after intravenous administration of contrast material, an optimal cut-off value of 54.43 HU was found to best discriminate between malignant and benign breast lesions (AUC=0.681; 95%CI: 0.558–0.805; P=0.006) yielding 69.0% sensitivity (95%CI: 56.9–79.5%) and 69.2% specificity (95% CI: 48.2–85.7%). At 2-min, an optimal cut-off value of 72.65 HU was found to best discriminate between malignant and benign breast lesions (AUC=0.654; 95%CI: 0.535–0.774; P=0.020) yielding 50.7% sensitivity (95%CI: 38.6–62.8%) and 80.8% specificity (95%CI: 60.6–93.4%). CE-CBCT helped differentiate between immunohistochemical subtypes of breast lesions with lowest enhancement for triple negative lesions. No differences in enhancement were found among histopathological subtypes lesions at 1-min (P=0.478) and 2-min (P=0.625).
Conclusion |
CE-CBCT helps discriminate between malignant and benign breast lesions, with best capabilities obtained at 1-min after intravenous administration of contrast material. For malignant lesions, quantitative analysis of enhancement on CE-CBCT helps differentiate between immunohistochemical subtypes.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Breast neoplasms, Cone beam computed tomography (CBCT), Contrast media, Discrimination, Sensitivity and specificity
Mappa
Vol 101 - N° 6
P. 391-399 - giugno 2020 Ritorno al numero
Articolo precedente
- Quantitative signal intensity ratios to distinguish between subfascial lipoma and atypical lipomatous tumor/well-differentiated liposarcoma using short-tau inversion recovery (STIR) MRI
- R. Donners, A.H. Krieg, D. Baumhoer, D.T. Boll, D. Harder
- Prediction of tumor grade and lymphovascular space invasion in endometrial adenocarcinoma with MR imaging-based radiomic analysis
- M. Bereby-Kahane, R. Dautry, E. Matzner-Lober, F. Cornelis, D. Sebbag-Sfez, V. Place, M. Mezzadri, P. Soyer, A. Dohan
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.