Hydroxychloroquine effects on psoriasis: A systematic review and a cautionary note for COVID-19 treatment - 23/07/20
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
Articolo gratuito.
Si connetta per beneficiarne
Abstract |
Background |
While evidence suggests that hydroxychloroquine (HCQ) may decrease the viral load in patients with a COVID-19 infection, a number of case reports indicate adverse dermatologic effects of this potential treatment.
Objective |
To conduct a systematic review of previously reported cases of psoriasis onset, exacerbation, or relapse after HCQ treatment.
Methods |
Embase and MEDLINE were comprehensively searched for original studies examining adverse effects of HCQ treatment related to psoriasis. Participant demographics and details of HCQ administration and psoriasis diagnosis were extracted from 15 articles representing 18 patients.
Results |
Women accounted for a significantly larger number of cases of psoriasis compared with men and unreported sex (14 [77.8%] vs 2 [11.1%] vs 2 [11.1%], respectively). In addition, 50% (n = 9) of the patients did not have a history of psoriasis before taking HCQ. Of the 18 patients, 9 (50.0%) experienced de novo psoriasis, 5 (27.8%) experienced exacerbation of psoriatic symptoms, and 4 (22.2%) had a relapse of psoriasis after HCQ administration.
Conclusion |
HCQ treatment may result in induction, exacerbation, or relapse of psoriasis. Monitoring for adverse effects of HCQ treatment is necessary, and clinical trials are essential in characterizing the safety profile of HCQ use in patients with a COVID-19 infection.
Il testo completo di questo articolo è disponibile in PDF.Key words : COVID-19, exacerbation, hydroxychloroquine, induction, Plaquenil, psoriasis, relapse
Abbreviations used : HCQ, IL
Mappa
| Funding sources: None. |
|
| Conflicts of interest: Dr Yeung has been a speaker, consultant, and investigator for AbbVie, Allergan, Amgen, Astellas, Boehringer Ingelheim, Celgene, Centocor, Coherus, Dermira, Eli Lilly, Forward, Galderma, GSK, Janssen, Leo, MedImmune, Merck, Novartis, Pfizer, Regeneron, Roche, Sanofi Genzyme, Takeda, UCB, Valeant, and Xenon. Ms Sachdeva, Mr Maliyar, and Drs Mufti and Lytvyn have no conflicts of interest to declare. |
|
| IRB approval status: Not applicable. |
|
| Reprints not available from the authors. |
Vol 83 - N° 2
P. 579-586 - agosto 2020 Ritorno al numero
Articolo precedente
- Characterizing the adverse dermatologic effects of hydroxychloroquine: A systematic review
- Ajay N. Sharma, Natasha A. Mesinkovska, Taraneh Paravar
- Thick melanoma is associated with low melanoma knowledge and low perceived health competence, but not delays in care
- Sophia H. Zhang, Rebecca Liu, Nalyn Siripong, John M. Kirkwood, Matthew P. Holtzman, Diwakar Davar, Yana Najjar, Keely Marshall, Stephanie R. Jackson Cullison, Neil A. Houston, Galen Switzer, Laura K. Ferris
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.