Blepharospasm, dry eye and extractable nuclear antigen antibodies - 18/08/20
, M. Abdellaoui a, b, G. de Saint Sauveur a, b, A. Huang a, b, P. Lévy c, d
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Summary |
Purpose |
To study whether there is an association between benign essential blepharospasm and Sjögren's syndrome by analyzing the presence of antibodies to extractable nuclear antigens in this population.
Methods |
Seventy-two patients with benign essential blepharospasm (BEB) were included in this study. We excluded patients with hemifacial spasm or blepharospasm secondary to known corneal pathology. We recorded results of Schirmer I testing as well as levels of anti-SSA/Ro and anti-SSB/La antibodies.
Results |
Our study included 72 patients (144 eyes), of which 62 (86.1%) were women. The mean age was 74.3±10.73 years. The mean Schirmer I test result was 3.14±4.00mm. Five women (8% of this female population) were found to have positive anti-SSA/Ro and anti-SSB/La antibodies. Their mean age was 65.66±13.24 years, while the mean age of the antibody-negative patients was 75.42±9.27 years. There was no statistically significant difference between the Schirmer I tests of the antibody positive and negative patients.
Conclusion |
This study demonstrates a possible association between Sjögren's syndrome and benign essential blepharospasm, justifying anti-SSA/Ro and anti-SSB/La testing in these patients.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Blepharospasm, Gougerot-Sjögren Syndrome, Dry eye syndrome, Dry eye, Schirmer's test, Extractable nuclear antigen antibodies, Anti-SSA/Ro antibodies, Anti-SSB/La antibodies, Botulinum toxin A
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Vol 43 - N° 7
P. e211-e215 - settembre 2020 Ritorno al numero
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