Exercise capacity in children with bronchopulmonary dysplasia at school age - 09/09/20
, Mandy Vogel b , Werner Siekmeyer a , Antje Körner a , Wieland Kiess a, b , Maike vom Hove a Abstract |
Objective |
To assess the exercise capacity, exercise habits, and lung function of preterm born children with bronchopulmonary dysplasia (BPD) compared to term born controls at school age.
Methods |
Cardiopulmonary exercise test (CPET) by cycle ergometer and pulmonary function test were performed in children with BPD (n = 42) and compared with a term born control group (n = 42). Daily activity, participation in sports and respiratory symptoms were assessed by questionnaire.
Results |
Children with BPD versus controls had significantly lower values for oxygen consumption (V̇O2 [mL/min] 1442 ± 417 vs. 1766 ± 541), minute ventilation (VE [L/min] 48 ± 14.92 vs. 60 ± 18.33), and workload (W [watt] 96.1 ± 16.7 vs. 110.6 ± 17.2) at peak exercise and a lower anaerobic threshold (VO2 AT [mL/min] 1183 ± 345 vs. 1382 ± 398). When corrected for weight, only for the workload (2.7 ± 0.5 vs. 3.1 ± 0.5, p = 0.0013) did significant differences persist. The forced expiratory volume in 1 s and forced expiratory flow between 25 and 75% of expired forced vital capacity were significantly reduced in the BPD group (p < 0.0001). Children with BPD have a higher risk of reporting difficulties in physical activity (OR 2.5) and of suffering from wheezing or shortness of breath while exercising (OR 2.5).
Conclusion |
Compared to term born controls, children with BPD at school age show airflow obstruction, a lower workload in CPET, and more respiratory symptoms related to physical activity. The comparable oxygen consumption based on weight suggests a functionally normal alveolar compartment.
Il testo completo di questo articolo è disponibile in PDF.Highlights |
• | Preterm born children show airflow obstruction and have a lower workload in CPET. |
• | Children with BPD have more difficulties and report more respiratory symptoms during physical activity. |
• | Physical activity levels corresponded to the controls, and adjusted for weight, respiratory CPET values were equivalent. |
• | Relevant associations between the pulmonary function variables and the CPET parameters were not found. |
• | The duration of oxygen supplementation and birth weight were inversely associated with peak VO2 and workload. |
Keywords : Lung function, Respiratory symptoms, Preterm, Very low birth weight, Cardiopulmonary exercise test, Cycle ergometry
Mappa
Vol 171
Articolo 106102- settembre 2020 Ritorno al numero
Articolo precedente
- Lung imaging in bronchopulmonary dysplasia: a systematic review
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