Avasimibe inhibits the proliferation, migration and invasion of glioma cells by suppressing linc00339 - 27/10/20
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Graphical abstract |
Highlights |
• | Avasimibe, an inhibitor of cholesterol acyltransferase 1, shows anti-tumour efficacy. |
• | We examined the action of Avasimibe in glioma cell lines. |
• | Avasimibe inhibits cell viability in glioma cell lines. |
• | Avasimibe inhibits the proliferation, migration and invasion of glioma cell lines. |
• | Avasimibe inhibits the proliferation, migration and invasion of glioma cell lines by suppressing linc00339. |
Abstract |
Glioma is one of the most destructive human tumours. Although standard treatment has improved the prognosis for glioma patients, the survival of glioma patients is still unsatisfactory. Avasimibe, an effective inhibitor of cholesterol acyltransferase 1 (ACAT1), has shown anti-tumour efficacy in many kinds of tumours. However, its role and related mechanism in glioma has not been fully elucidated. In the present study, we show that avasimibe effectively inhibits the proliferation, migration and invasion of glioma cell lines. Through LncRNA microarrays, we found that linc00339 levels were closely related to the anti-tumour effect of avasimibe. With the help of a series of functional assays, we show that avasimibe inhibits the proliferation, migration and invasion of glioma cell lines by suppressing linc00339 in vitro and in vivo. Our findings may provide a new approach for glioma therapy.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Avasimibe, Cholesterol acyltransferase 1, Long non-coding RNA, Linc00339, Glioma
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Vol 130
Articolo 110508- Ottobre 2020 Ritorno al numeroBenvenuto su EM|consulte, il riferimento dei professionisti della salute.
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