Immune dyscrasia in adult growth hormone deficiency: Evaluation of hemolytic complement activity (CH50) and IgG subclasses - 28/10/20
, Antonio Mancini a, c, ⁎ Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
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Graphical abstract |
Highlights |
• | Adult Growth Hormone Deficiency (aGHD) is marked by low grade chronic inflammation. |
• | aGHD is characterized by low IgG production, particularly IgG1 and IgG2. |
• | CH50 is higher in aGHD than healthy subjects, even though still in normal range. |
• | Lower IgG production is coupled with increased free light chains secretion in aGHD. |
• | Besides the dyscrasia in IgG production, no worse immune response can be described. |
Abstract |
CH50 is a screening assay for the activation of the classical complement pathway, the immunoglobulins-mediated one, activated in several inflammatory diseases. Adult growth hormone deficiency (aGHD) is recognized as a chronic inflammatory condition, although poorly evaluated under the profile of inflammatory biomarkers. The aim of this case-control observational study is to analyze CH50 and immunoglobulins G (IgG) subclasses production in aGHD, comparing this condition to healthy controls.
38 subjects were included and divided as follows: aGHD (n = 18, 6 females and 12 males); healthy controls (n = 20, 10 females and 10 males). GHD was diagnosed with dynamic test using Growth Hormone-Releasing Hormone (GHRH 50 μg i.v. + arginine 0,5 g/Kg), with a peak GH response < 9 μg/L when BMI was <30 kg/m2 or < 4 μg/L when BMI was >30 kg/m2. The two groups were evaluated for hormonal and metabolic parameters, CH50 and IgG subtypes.
IgG1 and IgG2 were significantly higher in controls than in aGHD, while IgG3 and IgG4 showed a trend to higher levels in controls, although not significant. Furthermore, CH50 levels were significantly higher in aGHD.
These data substantiate the hypothesis of a dyscrasia in IgG subclasses production in aGHD. As IgG levels decrease, CH50 levels do not.
Il testo completo di questo articolo è disponibile in PDF.Abbreviations : Adult, Oxidative, Low-grade, Free, Insulin-like, Complement, Growth, Growth, Thyroid-stimulating, Follicle-stimulating, Luteinizing, Estradiol, Testosterone, Glucose-6-phosphate, Standard, Monocyte, Primary
Keywords : CH50, GHD, Immunoglobulins, Low grade chronic inflammation, Free light chains
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Articolo 110757- novembre 2020 Ritorno al numero
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