Predicting long-term mortality with two different criteria of exercise-induced desaturation in COPD - 11/05/21
Abstract |
Background |
There are few reports on exercise-induced desaturation (EID) as a predictor of mortality in chronic obstructive pulmonary disease (COPD). However, the definitions of EID vary in published reports. The main purpose was to evaluate the association between EID and long-term mortality by applying two criteria of EID.
Methods |
A total of 507 subjects were selected from the Korean Obstructive Lung Disease cohort. EID was assessed using the 6-min walk test (6MWT) and defined using two different criteria [1]: post-6MWT oxygen saturation (SpO2) of ≤88% (criterion A) and [2] post-6MWT SpO2 < 90% or a decrease of ≥4% compared to baseline (criterion B).
Results |
The prevalence of EID was 5.1% based on criterion A and 13.0% based on criterion B. Regardless of the criteria used, mortality was higher in the EID group than in the non-EID group (A: 50 vs. 11.4%, B: 33.3 vs. 10.4%) during up to 161 months of follow-up. COPD patients without EID survived significantly longer than those with EID (A: 143.5 vs. 92.9, B: 144.8 vs. 115.2 months). Multivariate Cox regression analysis revealed that COPD patients with EID had a 2.4-fold increased risk of death by criterion A (adjusted HR 2.375; 95% CI: 1.217–4.637; P = 0.011). The risk of death increased in COPD patients with EID by criterion B, but the difference was not statistically significant.
Conclusions |
COPD patients with EID demonstrated significantly higher long-term mortality than those without EID. The EID criterion A has a better predictive value for mortality in COPD.
Il testo completo di questo articolo è disponibile in PDF.Highlights |
• | The prevalence of EID increases with the severity of airflow limitation in patients with COPD. |
• | COPD patients without EID survived significantly longer than those with EID. |
• | COPD patients with EID had a 2.4-fold increased risk of death. |
• | The EID criterion of post-6MWT SpO2 of ≤88% has a better predictive value for mortality. |
Keywords : Chronic obstructive pulmonary disease, Exercise-induced desaturation, Mortality
Mappa
Vol 182
Articolo 106393- giugno 2021 Ritorno al numero
Articolo precedente
- Fibroblast growth factor 23 is an independent marker of COPD and is associated with impairment of pulmonary function and diffusing capacity
- M. Kraen, S. Frantz, U. Nihlén, G. Engström, C.G. Löfdahl, P. Wollmer, M. Dencker
- A 28-day clinical trial of aerosolized hyaluronan in alpha-1 antiprotease deficiency COPD using desmosine as a surrogate marker for drug efficacy
- Jerome O. Cantor, Shuren Ma, Xingjian Liu, Michael A. Campos, Charlton Strange, James M. Stocks, Megan S. Devine, Sherif G. El Bayadi, Randolph J. Lipchik, Robert A. Sandhaus, Gerard M. Turino
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?