Parathyroid identification during thyroid and parathyroid operations: A pilot study evaluating a novel low cost autofluorescence based device - 20/05/21
, Nima Saleh b , Amir Tootooni b , Parisa Eshraghi b , Randy Jama b , Sina Saleh b Abstract |
Background |
The aim of this study was to develop a low-cost prototype near-infrared fluorescence device that enables contrast-free, real time, high-resolution intraoperative visualization of normal and pathological parathyroid glands (PGs) by imaging their autofluorescence (AF).
Methods |
A novel near-infrared parathyroid AF (NIR-PAF) imaging device with visible laser PG targeting was developed. The device was evaluated during parathyroid and thyroid operations in a pilot clinical study.
Results |
Overall, of the 6 parathyroidectomies carried out in the study population a parathyroid adenoma was found to exhibit AF ex vivo in 6/6 (100%) of cases, and in vivo in 3/3 (100%) of these cases. Two of 4 thyroidectomies were evaluated in vivo and all PGs (6 PGs total) were identified by the NIR-PAF device. The NIRPAF device cost less than $1200 Canadian to build.
Conclusion |
The inexpensive NIR-PAF device that we developed can successfully intraoperatively identify both normal and pathological PGs.
Il testo completo di questo articolo è disponibile in PDF.Highlights |
• | Near-infrared parathyroid autofluoresence (NIR-PAF) assists with parathyroid identification. |
• | A novel prototype NIR-PAF autofluoresence imaging device was developed. |
• | A surgeon and team of engineers designed, built, and tested the device. |
• | The device was able to accurately identify normal parathyroid glands and adenomas in a pilot study. |
• | The NIR-PAF device cost less than $1000 Canadian to build. |
Keywords : Parathyroid, Thyroid, Surgery, Autofluorescence, Near-infrared imaging
JEL classification : Endocrine
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Vol 221 - N° 6
P. 1150-1158 - giugno 2021 Ritorno al numero
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