Hyper-activated platelet lysates prevent glucocorticoid-associated femoral head necrosis by regulating autophagy - 02/06/21
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Abstract |
Platelet Rich Plasma (PRP) can activate angiogenic and osteogenic pathways, making it a highly promising therapeutic agent for bone growth. Super active platelet lysate (sPL) is derived from platelet-rich plasma (PRP) through ultra-low temperature freeze-thawing. The aim of this study was to evaluate the potential therapeutic effect of sPL on glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH). sPL increased the proliferation of GC-treated osteoblasts and endothelial cells, and inhibited apoptosis in vitro. Furthermore, sPL promoted healing of necrotic bone tissues in a rat ONFH model by restraining GC-induced apoptosis and increase autophagy of the osteoblasts. Overall, the results of this study provide a theoretical basis for the clinical application of sPL in ONFH.
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Highlights |
• | sPL promoted the proliferation of osteoblasts and endothelial cells, and inhibited cell apoptosis. |
• | In vivo experiments show that sPL increase autophagy, blood vessel formation and bone formation, reduce bone resorption. |
• | The addition of sPL will help to better prevent the functional ability and progress of ONFH. |
Keywords : Platelet-rich lysate, Osteonecrosis of the femoral head, Autophagy, MTOR, LC3
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Vol 139
Articolo 111711- luglio 2021 Ritorno al numero
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