Preoperative prognostic nutritional index predicts risk of recurrence after curative resection for stage IIA colon cancer - 15/06/21
, Mitsugi Shimoda b, Hiroyuki Hakoda c, Akihiro Sako c, Kazumitsu Ueda d, Shuji Suzuki bAbstract |
Background |
Preoperative nutritional and inflammatory indices have been reported to be associated with the prognosis of patients with malignancy. We evaluated clinicopathological factors, including nutritional and inflammatory indices, and recurrence prognosis in patients with stage IIA colon cancer (CC) who underwent curative surgery.
Methods |
This retrospective study included 197 patients with stage IIA CC who had undergone curative resection. We evaluated the association between prognostic nutritional index (PNI), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) with clinicopathological factors and prognosis for recurrence. For the recurrence-free survival (RFS) analysis, receiver operating characteristic (ROC) curves were used to determine appropriate cutoff values for PNI, NLR, and PLR.
Results |
Univariate analyses showed that PNI<44.8 (P = 0.028) was significantly associated with worse RFS in patients with stage IIA CC patients. In the multivariate analyses, PNI<44.8 (hazard ratio [HR] 2.082; 95% confidence interval [CI] 1.005–4.317; P = 0.049) independently and significantly predicted RFS.
Conclusion |
PNI is a useful marker for predicting recurrence prognosis in post-resection patients with stage IIA CC.
Il testo completo di questo articolo è disponibile in PDF.Highlights |
• | Preoperative PNI is associated with RFS in patients with stage IIA colon cancer after curative resection. |
• | PNI should be included in the preoperative evaluation of patients with stage IIA CC. |
• | This value can be used to determine if a patient should undergo adjuvant chemotherapy after resection surgery. |
Keywords : Prognostic nutritional index, Stage IIA colon Cancer, Adjuvant chemotherapy
Mappa
Vol 222 - N° 1
P. 179-185 - luglio 2021 Ritorno al numero
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