Systemic biomarkers currently implicated in the formation of abdominal wall hernia: A systematic review of the literature - 15/06/21
Abstract |
Background |
Surgery to the abdominal wall is ubiquitous worldwide and hernia treatment is challenging and expensive, posing a critical need to tailor treatment to individual patient risk-factors. In this systematic review, we consider specific systemic factors with potential as biomarkers of hernia formation.
Methods |
A healthcare database-assisted search, following PRISMA guidelines, identified journal articles for inclusion and analysis.
Results |
14 biomarker studies were selected, comparing hernia patients and hernia-free controls, focusing on markers of extracellular matrix (ECM) remodelling and collagen turnover. Matrix metalloproteinase-2 was increased in patients with inguinal hernia. Markers of type IV collagen synthesis were increased in patients with abdominal wall hernia; while markers of fibrillar collagen synthesis were reduced. Additional other ECM signalling proteins differ significantly within published studies.
Conclusion |
We identify a lack of high-quality evidence of systemic biomarkers in tailoring treatment strategies relative to patient-specific risks, but recognise the potential held within biomarker-based diagnostic studies to improve management of hernia pathogeneses.
Il testo completo di questo articolo è disponibile in PDF.Highlights |
• | Biomarkers of ECM remodelling may play a significant role in reducing future hernia-related morbidity. |
• | MMP-2 is elevated in subjects with inguinal hernia. |
• | P4NP may predict hernia development. |
• | Reduced fibrillar collagen synthesis is associated with abdominal wall hernia. |
• | Standardisation need be incorporated into future risk-assessment biomarker studies. |
Keywords : Hernia, Inguinal hernia, Incisional hernia, Biomarkers, Extracellular matrix (ECM) remodelling, Collagen turnover
Mappa
Vol 222 - N° 1
P. 56-66 - luglio 2021 Ritorno al numero
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