The intraperitoneal ondansetron for postoperative pain management following laparoscopic cholecystectomy: A proof-of-concept, double-blind, placebo-controlled trial - 17/06/21
, Sherif Boraii c , Ejaz Cheema d, ⁎, 2 , Mohamed Hassan Elnaem e, f, 3 , Tamer Omar g, 4 , Amr Abdelraouf c , Noha O. Mansour h Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
| pagine | 6 |
| Iconografia | 3 |
| Video | 0 |
| Altro | 0 |
Abstract |
Background |
Pain after laparoscopic cholecystectomy remains a major challenge. Ondansetron blocks sodium channels and may have local anesthetic properties.
Aims |
To investigate the effect of intraperitoneal administration of ondansetron for postoperative pain management as an adjuvant to intravenous acetaminophen in patients undergoing laparoscopic cholecystectomy.
Methods |
Patients scheduled for elective laparoscopic cholecystectomy were randomized into two groups (n = 25 each) to receive either intraperitoneal ondansetron or saline injected in the gall bladder bed at the end of the procedure. The primary outcome was the difference in pain from baseline to 24-h post-operative assessed by comparing the area under the curve of visual analog score between the two groups.
Results |
The derived area under response curve of visual analog scores in the ondansetron group (735.8 ± 418.3) was 33.97% lower than ( p = 0.005) that calculated for the control group (1114.4 ± 423.9). The need for rescue analgesia was significantly lower in the ondansetron (16%) versus in the control group (54.17%) ( p = 0.005), indicating better pain control. The correlation between the time for unassisted mobilization and the area under response curve of visual analog scores signified the positive analgesic influence of ondansetron ( r s = 0.315, p = 0.028). The frequency of nausea and vomiting was significantly lower in patients who received ondansetron than that reported in the control group ( p = 0.023 (8 h), and 0.016 (24 h) respectively).
Conclusions |
The added positive impact of ondansetron on postoperative pain control alongside its anti-emetic effect made it a unique novel option for patients undergoing laparoscopic cholecystectomy.
Il testo completo di questo articolo è disponibile in PDF.Graphical Abstract |
Highlights |
• | Pain after laparoscopic cholecystectomy usually delays hospital discharge. |
• | Postoperative use of acetaminophen alone is mostly insufficient to control pain. |
• | Intraperitoneal ondansetron improved the analgesic efficacy of acetaminophen. |
• | Intraperitoneal ondansetron lowered nausea and vomiting frequency post-surgery. |
• | The local anesthetic effect of ondansetron made it a novel option to manage pain. |
Keywords : Ondansetron, 5-HT 3 antagonists , Pain, Laparoscopic cholecystectomy
Mappa
Vol 140
Articolo 111725- agosto 2021 Ritorno al numero
Articolo precedente
- Effect of zinc oxide nanoparticles and ferulic acid on renal ischemia/reperfusion injury: possible underlying mechanisms
- Amira Awadalla, Abdelaziz M. Hussein, Yousra M. El-Far, Nashwa Barakat, Eman T. Hamam, Mohamed El-Sherbiny, Mohamed El-Shafey, Ahmed A. Shokeir
- Synthetic E-guggulsterone derivative GSD-1 inhibits NF-κB signaling and suppresses the metastatic potential of breast cancer cells
- Amira A. Abdellatef, Yue Zhou, Akane Yamada, Sahar A. Elmekkawy, Aki Kohyama, Satoru Yokoyama, Meselhy R. Meselhy, Yuji Matsuya, Hiroaki Sakurai, Yoshihiro Hayakawa
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?