Multiple hepatocellular carcinoma: Long-term outcomes following resection beyond actual guidelines. An Italian multicentric retrospective study - 12/08/21
, Tommaso Nelli a, Nadia Russolillo b, Alessandro Cucchetti c, Benedetta Pesi a, Luca Moraldi d, Alessandro Ferrero b, Giorgio Ercolani c, Gianluca Grazi e, Giacomo Batignani aAbstract |
Background |
Hepatocellular carcinoma (HCC) is frequently diagnosed as multinodular. This study aims to assess prognostic factors for survival and identify patients with multiple HCC who may benefit from surgery beyond the Barcelona Clinic Liver Cancer classification indications.
Methods |
This retrospective study included all the consecutive patients from 4 Italian tertiary centers receiving liver resection for naive multiple HCC between 1990 and 2012 to have a potential follow-up of 5 years.
Results |
Included patients were 144. Ninety-day morbidity and mortality rates were 38.3% and 8.3%, respectively. The 5-year overall and disease-free survival rates were 33.3% and 19.1%, respectively. Tumor size <3 cm, bilirubin, Child-Pugh A, BCLC-A stage, being within “up-to-7” criteria, and minor resections resulted in prognostic factors. The Child-Pugh score resulted in an independent prognostic factor.
Conclusions |
Surgery may be related to good outcomes in selected patients with multiple HCC.
Il testo completo di questo articolo è disponibile in PDF.Highlights |
• | Actual guidelines provide strict indications for hepatocellular carcinoma resection. |
• | Retrospective evaluation of patients resected for multiple hepatocellular carcinomas. |
• | The Child-Pugh score found as an independent prognostic factor for overall survival. |
• | Good outcomes may be achieved with surgery performed beyond the actual guidelines. |
Keywords : Multiple HCC, Liver resection, Liver surgery indication, Guidelines, Prognostic factors
Mappa
Vol 222 - N° 3
P. 599-605 - settembre 2021 Ritorno al numero
Articolo precedente
- Open hepatic resection in the elderly at two tertiary referral centers
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