Hydrogel-coated needles prevent puncture site bleeding in arteriovenous fistula and arteriovenous grafts in rats - 09/10/21
, Jing’an Li d, ⁎ Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
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Abstract |
Introduction |
Imperfect hemostasis after arteriovenous fistula (AVF) and arteriovenous graft (AVG) cannulation can cause a hematoma or pseudoaneurysm and leads to poor satisfaction. We hypothesized that a hydrogel-coated needle would effectively and rapidly stop bleeding after vascular cannulation in a rat AVF and AVG model.
Method |
A hydrogel comprised of sodium alginate (SA), hyaluronic acid (HA), and calcium carbonate was coated onto the surface of suture needles using a rotating system. The needles were observed using scanning electron microscopy (SEM) and immunofluorescence. Rat AVF with or without renal failure and AVG were punctured using bare and hydrogel-coated needles. The tissues were examined by histology.
Result |
The hydrogel was successfully coated onto the surface of 30 G needles and confirmed by SEM. Hydrogel-coated needles rapidly stopped bleeding after AVF and AVG cannulation in rat.
Conclusion |
In this preliminary animal research, hydrogel-coated needles can stop AVF and AVG puncture-site bleeding; but additional clinical studies are needed to justify whether it is still effective in clinical.
Il testo completo di questo articolo è disponibile in PDF.Graphical abstract |
Highlights |
• | Hydrogel-coated needles stopped the AVF and AVG puncture-site bleeding in rat. |
• | A new arteriovenous graft model was established in rat. |
• | The coating process can be easily achieved by a self-made rotating system. |
Keywords : Hemostasis, Hydrogel, Needle, Arteriovenous fistula, Arteriovenous graft, Puncture, Cannulation
Mappa
Vol 143
Articolo 112113- novembre 2021 Ritorno al numero
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