Severe asthma in Kuwait population: Phenotype-based approach - 19/10/21
, Jasmina Nurkic b , Yasmine Othman b , Edin Jusufovic c , Ahmed Maher b Abstract |
Background |
There is increasing recognition of marked phenotypic heterogeneity within severe asthma patients.
Methods |
Severe asthma patients on GINA step 4 or 5 treatment, followed up at Al-Rashed Allergy center Kuwait, were evaluated for: demographics (gender, age, age of asthma onset), comorbidities (allergic rhinitis (AR), chronic rhinosinusitis (CRS), chronic rhinosinusitis with nasal polyposis (CRSwNP), obesity), blood biomarkers (total serum Immunoglobulin E (IgE), peripheral eosinophils), and sensitization to inhalants allergens.
Results |
A total of 169 patients were candidates for biological treatment. Patients were divided in two groups based on level of total IgE as a “low” group with IgE<160 IU/ml (n = 55) and “high” group with IgE≥ 160 IU/ml (n = 114). Both groups were further divided in subgroups, “low” and “high”, based on absolute number of eosinophils (Eos) in peripheral blood with <300 cells/μl or ≥ 300 cells/μl. Only 10% of patients were in low IgE/low Eos while majority (46%) were in the high IgE/high Eos group. Mean age of patients was 44.1 year with domination of females (n = 123). Majority of patients were obese. AR, CRS and CRSwNP were more common in group with IgE ≥160 IU/ml, while CRS and CRSwNP in group with Eos ≥300 cells/μl.
Conclusion |
The majority of severe asthma patients in Kuwait are obese females with adult-onset asthma (>18 years of age) who were allergic with comorbid conditions including AR, CRS and CRSwNP, which correlates well with the level of Eos.
Il testo completo di questo articolo è disponibile in PDF.Highlights |
• | Assessment of blood biomarkers ie. sIgE and blood EOS can identify severe asthma patients eligible for biological treatment. |
• | Obese females with adult-onset asthma and atopy predominate among severe, uncontrolled asthma patients in Kuwait. |
• | Co-morbidities such as allergic rhinitis and chronic rhinosinusitis with or without NPs correlate with blood EOS levels. |
Keywords : Severe asthma, Phenotype, Allergic, Eosinophilic
Abbreviations : GINA, IgE, Eo, BMI, IL-5, IL-5r, sIgE, SPT, AR, CRS, CRSwNP, BAL, FeNO
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Vol 187
Articolo 106586- ottobre 2021 Ritorno al numero
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