Oxyhemoglobin concentrations do not support hemoglobinopathy in COVID-19 - 19/10/21
, Hamna Zafar b, Kusum Mathews b
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Abstract |
Based on computerized modeling studies, it has been postulated that the severe hypoxemia in COVID-19 may result from impaired oxygen carrying capacity on hemoglobin. Standard pulse oximetry may not detect hypoxemia resulting from hemoglobinopathy, therefore hemoglobin co-oximetry is needed to evaluate this divergence. In a clinical data analysis of a multicenter cohort of hospitalized patients with COVID-19, we found a minimal effect, less than 1%, on the correlation between oxyhemoglobin concentration and predicted oxygen saturation in the presence of COVID-19 infection. This effect is unlikely to explain the clinically significant hypoxia in COVID-19 patients.
Il testo completo di questo articolo è disponibile in PDF.Highlights |
• | Hemoglobinopathy associated with COVID-19 has been proposed to explain findings of severe hypoxia. |
• | Oxyhemoglobin levels in COVID-19 patients do not show clinically significant differences from estimated hemoglobin saturation levels. |
• | Hemoglobinopathy likely does not account for significant differences in oxygenation in patients with COVID-19 disease. |
Keywords : COVID-19, Hypoxia, Respiratory failure, Hemoglobinopathy
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Vol 187
Articolo 106597- ottobre 2021 Ritorno al numero
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