Initial rhythm control with cryoballoon ablation vs drug therapy: Impact on quality of life and symptoms - 30/10/21
, Gian-Battista Chierchia, MD b, 1, Vedran Velagic, MD c, Jean Sylvain Hermida, MD d, Stewart Healey, MD e, Giuseppe Arena, MD f, Nicolas Badenco, MD g, Christian Meyer, MD h, Jian Chen, MD i, Saverio Iacopino, MD j, Frédéric Anselme, MD k, Lukas Dekker, MD l, Fernando Scazzuso, MD m, Douglas L Packer, MD n, Carlo de Asmundis, MD b, Heinz-Friedrich Pitschner, MD o, Fabio Di Piazza, MSc p, Rachelle E Kaplon, PhD q, Malte Kuniss, MD oCryo-FIRST Investigators2
Riassunto |
Background |
Cryoballoon ablation (CBA) as a first-line rhythm control strategy is superior to antiarrhythmic drugs (AADs) for preventing atrial fibrillation (AF) recurrence; the impact of first-line CBA on quality of life (QoL) and symptoms has not been well characterized.
Methods |
Patients aged 18 to 75 with symptomatic paroxysmal AF naïve to rhythm control therapy were randomized (1:1) to CBA (Arctic Front Advance, Medtronic) or AAD (Class I or III). Symptoms and QoL were assessed at baseline, 1, 3, 6, 9, and 12 months using the EHRA classification and Atrial Fibrillation Effect on QualiTy-of-Life (AFEQT) and SF-36v2 questionnaires. Symptomatic palpitations were evaluated via patient diary.
Results |
Overall, 107 patients were randomized to CBA and 111 to AAD; crossovers occurred in 9%. Larger improvements in the AFEQT summary, subscale and treatment satisfaction scores were observed at 12 months with CBA vs AAD (all P <0.05). At 12 months, the mean adjusted difference in the AFEQT summary score was 9.9 points higher in the CBA group (95% CI: 5.5 –14.2, P <0.001). Clinically important improvements in the SF-36 physical and mental component scores were observed at 12 months in both groups, with no significant between group differences at this timepoint. In the CBA vs AAD group, larger improvements in EHRA class were observed at 6, 9 and 12 months (P <0.05) and the incidence rate of symptomatic palpitations was lower (4.6 vs 15.2 days/year post-blanking; IRR: 0.30, P <0.001).
Conclusions |
In patients with symptomatic AF, first-line CBA was superior to AAD for improving AF-specific QoL and symptoms.
Trial registration |
ClinicalTrials.gov number: NCT01803438.
Il testo completo di questo articolo è disponibile in PDF.Graphical abstract |
Mappa
Vol 242
P. 103-114 - dicembre 2021 Ritorno al numero
Articolo precedente
- Cardiovascular risk and outcomes in symptomatic patients with suspected coronary artery disease and non coronary vascular disease: A report from the PROMISE trial
- Sreekanth Vemulapalli, Amanda Stebbins, W. Schuyler Jones, J. Antonio Gutierrez, Manesh R. Patel, Rowena J. Dolor, Patricia A. Pellikka, Brooke Alhanti, Udo Hoffmann, Pamela S. Douglas
- Increased risk of ischemic stroke and systemic embolism in hyperthyroidism-related atrial fibrillation: A nationwide cohort study
- Kyu Kim, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y.H. Lip, Boyoung Joung
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?