Rhinosinusitis without nasal polyps is associated with poorer health-related quality of life in COPD - 08/12/21
, Malcolm Sue-Chu c, d , Anne-Sofie Helvik a, e , Sverre Karmhus Steinsvåg f, g , Silje Steinsbekk h , Wenche Moe Thorstensen a, b Abstract |
Rhinosinusitis without nasal polyps (RSsNP) is prevalent in COPD. Previous studies on its association with health-related quality of life (HRQoL) have limitations, and RSsNP is currently not recognized as a comorbidity. This study investigates HRQoL in COPD including a focus on RSsNP.
Generic HRQoL was assessed with the Short Form-36 (SF-36v2) questionnaire and compared between 90 COPD and 93 control subjects and in subgroups with and without RSsNP. The association between RSsNP and COPD versus not and generic HRQoL was assessed by multivariable linear regression with adjustments for age, education, and body mass index (BMI). Disease-specific HRQoL was assessed by Sinonasal outcome test-22 (SNOT-22), St. Georges Respiratory Questionnaire (SGRQ), and COPD Assessment Test (CAT) and compared between COPD with and without RSsNP, and their association to RSsNP was assessed by multivariable linear regression with adjustments for age, BMI, and FEV1% predicted.
RSsNP was associated with poorer disease-specific HRQoL, with higher SNOT-22 total score (14.67 points; 95% CI, 7.06–22.28; P < .001) and psychological subscale score (3.24 points; 95% CI, 0.37–6.11; P = .03), SGRQ symptom score (13.08 points; 95% CI, 2.73–23.4; P = .014), and CAT score (4.41 points; 95% CI, 1.15–7.66; P = .009).
Generic HRQoL was poorer in COPD patients than in the control subjects. In addition to COPD, concomitant RSsNP was associated with poorer physical functioning, general health, vitality, and physical component summary.
RSsNP in COPD is associated with poorer disease-specific HRQoL that is clinically relevant and, as it is amenable for treatment, should be recognized as a comorbidity of COPD.
Il testo completo di questo articolo è disponibile in PDF.Highlights |
• | RSsNP is associated with poorer overall disease-specific HRQoL in COPD. |
• | COPD patients with RSsNP experience higher COPD symptom burden and activity limitation. |
• | COPD patients with RSsNP have more psychological issues, e.g., sadness, fatigue, and reduced productivity. |
• | Treatment of RSsNP may contribute to a clinically meaningful change in HRQoL in COPD. |
• | RSsNP in COPD has clinical relevance and should be recognized as a comorbidity. |
Keywords : COPD, Rhinosinusitis, HRQoL, Comorbidity, United airway disease
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Vol 189
Articolo 106661- novembre 2021 Ritorno al numero
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