Are sputum eosinophils associated with a different phenotype in COPD patients? A retrospective study - 08/12/21
Abstract |
Sputum eosinophilia in Chronic Obstructive Pulmonary Disease (COPD) patients seems to be associated with a better response to inhaled corticosteroids (ICS). To verify if this feature could identify a specific subpopulation of COPD patients, we retrospectively compared functional and inflammatory parameters of 110 COPD patients according to the presence of sputum eosinophilia (>2%). Patient with eosinophilia were characterized by lower dyspnea score, lower functional impairment and lower ICS use, suggesting that airway eosinophilia may be associated to a lower COPD severity and some functional “asthma-like” characteristics, therefore explaining the better response to ICS in this subgroup of patients.
Il testo completo di questo articolo è disponibile in PDF.Highlights |
- | Sputum eosinophils, seldom measured in COPD patients, may offer useful informations. |
- | Sputum eosinophilia is associated with lower level of COPD severity. |
- | COPD patients with sputum eosinophilia have a prominent “bronchiolitic” phenotype. |
- | They are less frequently treated with ICS, but may receive some advantage from them. |
Keywords : COPD, Sputum, Eosinophilia, Severity
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Vol 190
Articolo 106672- dicembre 2021 Ritorno al numero
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