Roles and mechanisms of quercetin on cardiac arrhythmia: A review - 31/08/22
Abstract |
Cardiac arrhythmia is one of the most prevalent cardiovascular diseases worldwide, which can occur alone or be triggered by other diseases, and it can be fatal in severe cases. Recently, Traditional Chinese Medicine has drawn the world’s attention to its effective treatment. As a natural polyhydroxy flavonoid mainly isolated from a variety of plants and foods, quercetin is used for the treatment of cardiovascular disease, cancer, autoimmune diseases, and neurological disorders. A growing number of in vitro experiments and in vivo animal studies have shown that quercetin significantly inhibits mitochondrial oxidative stress, cardiac fibrosis, inflammatory responses, and apoptosis, regulates autophagic responses, improves ischemia/reperfusion injury in cardiomyocytes, and regulates gut microbiota, thereby attenuating or preventing structural and electrical remodeling in the cardiac. Based on these mechanisms, our review provides a systematic overview of the pharmacological actions and molecular targets of quercetin in cardiac arrhythmia caused by multiple etiologies, aiming to provide novel insights and therapeutic strategies to prevent or ameliorate arrhythmia.
Il testo completo di questo articolo è disponibile in PDF.Graphical Abstract |
Highlights |
• | Arrhythmia is a commonly occurring cardiac problem worldwide. |
• | Quercetin has great potential in the treatment of cardiac arrhythmia. |
• | Quercetin could cure cardiac arrhythmia through multiple mechanisms and signaling pathways. |
• | This review provides a comprehensive clarification of the benefits of Quercetin on cardiac arrhythmia. |
• | This review is also concerned with the pharmacokinetics of Quercetin. |
Abbreviations : AF, HF, TCM, PEG200, QT-HNCs, ATP, ROS, NADPH, NOX, NO, SOD, GSH-Px/GSSG-Rd, AngⅡ, TNF-α, ET-1, I/R, NADH, CaMKⅡ, NHE, APD, EADs, NCX, PKC, VGSCs, PKA, cGMP, PKG, SareKATP, MitoKATP, PI3K, RyR2, SR, SERCA, DADs, GJ, Cx40, Cx43, Cx45, RAAS, ACEI, mito-TEMPO, GJIC, ERK1/2, mPTP, IMAC, ΔΨ, RIRR, CsA, OS, CypD, CaW, HUVECs, EMC, CMR, SCD, α-SMA, TGF-β1, CTGF, ISO, SIRT1, NF-κB, DETC, MDA, CRP, IL-1, IL-6, IL-8, JNK, EAM, FOXO1, Akt, NLRP3, NLRs, Keap 1, Nrf2, TLR4, HMGB1, CK, LDH, LPS, TLR, MAPK, AMI, NOX2, NOX4, eNOS, MFN, Drp1, Bax, Bcl-2, AMPK, mTOR, LC3B-II, LAMP2, ATG7, LC3, Nd2O3, TMAO, SCFA, PCS, IS, GPR, Olfr78, HDAC, TCA, QOL
Keywords : Quercetin, Arrhythmia, Traditional Chinese Medicine, Pharmacological effect
Mappa
Vol 153
Articolo 113447- Settembre 2022 Ritorno al numeroBenvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?