Cerebral microvascular complications associated with SARS-CoV-2 infection: How did it occur and how should it be treated? - 10/09/22
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Abstract |
Cerebral microvascular disease has been reported as a central feature of the neurological disorders in patients with SARS-CoV-2 infection that may be associated with an increased risk of ischemic stroke. The main pathomechanism in the development of cerebrovascular injury due to SARS-CoV-2 infection can be a consequence of endothelial cell dysfunction as a structural part of the blood-brain barrier (BBB), which may be accompanied by increased inflammatory response and thrombocytopenia along with blood coagulation disorders. In this review, we described the properties of the BBB, the neurotropism behavior of SARS-CoV-2, and the possible mechanisms of damage to the CNS microvascular upon SARS-CoV-2 infection.
Il testo completo di questo articolo è disponibile in PDF.Graphical Abstract |
Highlights |
• | Endothelial dysfunction in Blood-Brain Barrier injures cerebrovascular in COVID-19. |
• | Hypercoagulation due to cerebral endothelial damage can cause stroke in COVID-19. |
• | Ischemic stroke due to SARS-CoV-2 infection is mostly present in younger patients. |
• | Anticoagulant therapy may improve cerebrovascular diseases in COVID-19 patients. |
• | Vaccine-induced immune thrombotic thrombocytopenia may rarely occur in some cases. |
Keywords : SARS-CoV-2, Neurological disorders, Cerebral microvascular, Blood-brain barrier, Inflammatory response, Neurotropism
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Vol 154
Articolo 113534- Ottobre 2022 Ritorno al numero
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